Meta-analysis of Mitochondrial Function Enhancement by Gongjindan Constituents
Journal · Mitochondrion (2023)
Original authors · Yoo JH, Shin HK, Kim YS, et al.
DOI · 10.1016/j.mito.2023.07.003
Summary
Sixteen studies (12 basic, 4 clinical) evaluating mitochondrial function effects of Gongjindan constituents (deer antler, musk, Angelica, Cornus officinalis) were meta-analyzed. ATP production increased by an average of 41%, with mitochondrial membrane potential significantly recovered. Notably, ligustilide from Angelica and loganin from Cornus officinalis were confirmed to play key roles in mitochondrial biogenesis (PGC-1α activation).
Key figures
ATP Production Increase
41%
Analyzed Studies
16 studies
Key Mechanism
PGC-1α
Conclusion
Gongjindan improves cellular energy metabolism through mitochondrial function enhancement, which is a core mechanism of its systemic tonic effects.
The summary, conclusion and key figures on this page were prepared by Geum Maek Korean Medical Clinic. Copyright of the original paper belongs to its authors, and the full text is not reproduced here. The original is available on the publisher page.
Findings were observed under specific study conditions and results may differ by individual. This does not replace medical consultation.