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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cross-Sectional Digestive Disorders

Effect of Herbal Medicine (Banhahubak-tang) on Functional Dyspepsia with Anxiety: A Cross-Sectional Analysis

Woo HS, Cho HJ, Nam DH, et al.

Functional Dyspepsia Research (2023)

160 patients Participants
38% Dyspepsia reduction
32% Anxiety reduction

Banhahubak-tang is effective for the simultaneous management of anxiety and functional dyspepsia.

View Source 2023
Cross-Sectional Digestive Disorders

Effect of Herbal Medicine (Banhahubak-tang) on Functional Dyspepsia with Anxiety: A Cross-Sectional Analysis

Woo HS, Cho HJ, Nam DH, et al. Functional Dyspepsia Research (2023)
160 patients Participants
38% Dyspepsia reduction
32% Anxiety reduction

Summary

Symptom differences were analyzed in 160 patients with functional dyspepsia comorbid with anxiety according to Banhahubak-tang use. Both FD symptoms (-38%) and anxiety (-32%) were significantly lower in the user group.

Key Conclusion

Banhahubak-tang is effective for the simultaneous management of anxiety and functional dyspepsia.

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Cohort Study Digestive Disorders

Cohort Study of Injinoryeong-san Herbal Medicine for Fatty Liver Disease

Cho KH, Jang EY, Moon PD, et al.

Hepatology (2024)

35% Hepatic Fat↓
140 subjects Participants
ALT Normalization Liver Function Improvement

Injinoryeong-san is effective in reducing hepatic fat and improving liver function in non-alcoholic fatty liver disease.

View Source 2024
Cohort Study Digestive Disorders

Cohort Study of Injinoryeong-san Herbal Medicine for Fatty Liver Disease

Cho KH, Jang EY, Moon PD, et al. Hepatology (2024)
35% Hepatic Fat↓
140 subjects Participants
ALT Normalization Liver Function Improvement

Summary

One hundred forty patients with non-alcoholic fatty liver disease were followed for 24 weeks, divided into Injinoryeong-san and non-treatment groups. The herbal group showed a 35% reduction in liver fat fraction (MRI-PDFF) and ALT normalization.

Key Conclusion

Injinoryeong-san is effective in reducing hepatic fat and improving liver function in non-alcoholic fatty liver disease.

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Before-After Digestive Disorders

Pre-Post Comparison Study of Modified Jakyakgamcho-tang for Ulcerative Colitis

Yang SB, Lee SG, Kim GH, et al.

Inflammatory Bowel Diseases (2024)

62% Mucosal Healing Rate
55 subjects Participants
3.2 points Mayo↓

Modified Jakyakgamcho-tang is effective in maintaining remission and promoting mucosal healing in ulcerative colitis.

View Source 2024
Before-After Digestive Disorders

Pre-Post Comparison Study of Modified Jakyakgamcho-tang for Ulcerative Colitis

Yang SB, Lee SG, Kim GH, et al. Inflammatory Bowel Diseases (2024)
62% Mucosal Healing Rate
55 subjects Participants
3.2 points Mayo↓

Summary

Fifty-five patients with ulcerative colitis in remission received modified Jakyakgamcho-tang for 12 weeks, with comparison of endoscopic and pathological findings. The mucosal healing rate was 62% and the Partial Mayo Score decreased by an average of 3.2 points.

Key Conclusion

Modified Jakyakgamcho-tang is effective in maintaining remission and promoting mucosal healing in ulcerative colitis.

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Systematic Review Digestive Disorders

Prebiotic Effect of Herbal Medicine on Gut Microbiota Imbalance: A Systematic Review

Kwak MA, Lee DH, Choi JY, et al.

Gut Microbes (2023)

22 studies Analyzed Papers
Beneficial bacteria↑ Prebiotic
Polysaccharides Active Components

Herbal medicine functions as a naturally derived prebiotic that promotes the proliferation of beneficial gut bacteria.

View Source 2023
Systematic Review Digestive Disorders

Prebiotic Effect of Herbal Medicine on Gut Microbiota Imbalance: A Systematic Review

Kwak MA, Lee DH, Choi JY, et al. Gut Microbes (2023)
22 studies Analyzed Papers
Beneficial bacteria↑ Prebiotic
Polysaccharides Active Components

Summary

Twenty-two studies evaluating the prebiotic effect of herbal medicine on gut microbiota were systematically reviewed. Polysaccharide components of herbal medicine promoted the proliferation of Bifidobacterium and Lactobacillus.

Key Conclusion

Herbal medicine functions as a naturally derived prebiotic that promotes the proliferation of beneficial gut bacteria.

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Before-After Digestive Disorders

Mucosal Protection Effect of Banhasasim-tang for Duodenal Ulcer: A Pre-Post Comparison

Jung WS, Lee AR, Park SJ, et al.

Ulcer Research (2024)

90% Healing Rate
40 subjects Participants
EGF↑ Mucosal Regeneration

Banhasasim-tang promotes mucosal protection and healing in duodenal ulcer.

View Source 2024
Before-After Digestive Disorders

Mucosal Protection Effect of Banhasasim-tang for Duodenal Ulcer: A Pre-Post Comparison

Jung WS, Lee AR, Park SJ, et al. Ulcer Research (2024)
90% Healing Rate
40 subjects Participants
EGF↑ Mucosal Regeneration

Summary

Forty patients with duodenal ulcer received Banhasasim-tang plus PPI for 8 weeks, with endoscopic evaluation. The ulcer healing rate was 90%, and mucosal regeneration markers (EGF) increased significantly.

Key Conclusion

Banhasasim-tang promotes mucosal protection and healing in duodenal ulcer.

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Meta-Analysis Digestive Disorders

Meta-analysis of Immunomodulatory Effects of Herbal Medicine for Inflammatory Bowel Disease

Kim TH, Song MY, Park CW, et al.

Journal of Crohns and Colitis (2024)

16 RCTs Analyzed RCTs
38% CRP↓
42% Calprotectin↓

Herbal medicine is an effective adjunctive treatment that suppresses intestinal inflammation in IBD.

View Source 2024
Meta-Analysis Digestive Disorders

Meta-analysis of Immunomodulatory Effects of Herbal Medicine for Inflammatory Bowel Disease

Kim TH, Song MY, Park CW, et al. Journal of Crohns and Colitis (2024)
16 RCTs Analyzed RCTs
38% CRP↓
42% Calprotectin↓

Summary

Sixteen RCTs evaluating the immunomodulatory effects of herbal medicine for IBD were meta-analyzed. The herbal adjunctive group showed significant reductions in CRP (-38%) and calprotectin (-42%).

Key Conclusion

Herbal medicine is an effective adjunctive treatment that suppresses intestinal inflammation in IBD.

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Case Study Digestive Disorders

Case Report of Modified Daesiho-tang for Cholecystitis

Yun YG, Seo DW, Han JM, et al.

Journal of Clinical Medicine (2023)

6 cases Case Number
5 improved Symptom Resolution
12 weeks Treatment Period

Modified Daesiho-tang may demonstrate efficacy in non-surgical management of acute cholecystitis.

View Source 2023
Case Study Digestive Disorders

Case Report of Modified Daesiho-tang for Cholecystitis

Yun YG, Seo DW, Han JM, et al. Journal of Clinical Medicine (2023)
6 cases Case Number
5 improved Symptom Resolution
12 weeks Treatment Period

Summary

Six patients with acute cholecystitis who refused surgery received modified Daesiho-tang plus Lonicera japonica for 12 weeks in a reported case series. Five patients showed complete resolution of symptoms, and gallbladder wall edema decreased on ultrasound.

Key Conclusion

Modified Daesiho-tang may demonstrate efficacy in non-surgical management of acute cholecystitis.

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Cross-Sectional Digestive Disorders

Dual Effect of Herbal Medicine on Acid Reflux with Comorbid Sleep Disturbance: A Cross-Sectional Analysis

Moon PD, Kang BK, Cho WS, et al.

Sleep and Digestive Disorders (2023)

140 subjects Participants
38% GERD↓
35% Sleep↑

Banhahubak-tang demonstrates a dual effect by simultaneously improving GERD and comorbid sleep disturbance.

View Source 2023
Cross-Sectional Digestive Disorders

Dual Effect of Herbal Medicine on Acid Reflux with Comorbid Sleep Disturbance: A Cross-Sectional Analysis

Moon PD, Kang BK, Cho WS, et al. Sleep and Digestive Disorders (2023)
140 subjects Participants
38% GERD↓
35% Sleep↑

Summary

Symptom differences according to herbal medicine (Banhahubak-tang) use were analyzed in 140 patients with GERD and comorbid sleep disturbance. The herbal use group showed significantly lower GERD-Q (-38%) and PSQI (-35%) scores.

Key Conclusion

Banhahubak-tang demonstrates a dual effect by simultaneously improving GERD and comorbid sleep disturbance.

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Narrative Review Digestive Disorders

Herbal Prescription Patterns by Sasang Constitution for Digestive Disorders: A Narrative Review

Chae HB, Lim BV, Kim KW, et al.

Journal of Sasang Constitutional Medicine (2024)

24 papers Reviewed Papers
4 constitutions Classification System
Tailored prescription Core Strategy

Sasang constitution-tailored prescription is essential for therapeutic efficacy and side-effect reduction in digestive disorders.

View Source 2024
Narrative Review Digestive Disorders

Herbal Prescription Patterns by Sasang Constitution for Digestive Disorders: A Narrative Review

Chae HB, Lim BV, Kim KW, et al. Journal of Sasang Constitutional Medicine (2024)
24 papers Reviewed Papers
4 constitutions Classification System
Tailored prescription Core Strategy

Summary

Twenty-four articles on herbal prescription patterns by Sasang constitution for digestive disorders were reviewed. Soeumin received Ijung-tang formulas, Taeumin received Taeumjowi-tang formulas, and Soyangin received Yangkyeoksanhwa-tang formulas predominantly.

Key Conclusion

Sasang constitution-tailored prescription is essential for therapeutic efficacy and side-effect reduction in digestive disorders.

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Systematic Review Digestive Disorders

Systematic Review of Topical Herbal Application (Gastric Patch) for Gastritis

Yoon HJ, Park BS, Kim SH, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

10 studies Analyzed Papers
Upper abdominal pain↓ Main Effect
External therapy Treatment Modality

Topical herbal gastric patches are useful as adjunctive external treatment for gastritis.

View Source 2023
Systematic Review Digestive Disorders

Systematic Review of Topical Herbal Application (Gastric Patch) for Gastritis

Yoon HJ, Park BS, Kim SH, et al. Evidence-Based Complementary and Alternative Medicine (2023)
10 studies Analyzed Papers
Upper abdominal pain↓ Main Effect
External therapy Treatment Modality

Summary

Ten studies evaluating the effect of topical herbal gastric patches on gastritis were systematically reviewed. Patch therapy demonstrated adjunctive improvement effects on upper abdominal pain and dyspeptic symptoms.

Key Conclusion

Topical herbal gastric patches are useful as adjunctive external treatment for gastritis.

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RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al.

Supportive Care in Cancer (2024)

55% Nausea↓
42% Appetite↑
60 subjects Participants

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

View Source 2024
RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al. Supportive Care in Cancer (2024)
55% Nausea↓
42% Appetite↑
60 subjects Participants

Summary

Sixty patients with chemotherapy-related digestive side effects (nausea, anorexia, diarrhea) were compared over 6 weeks between Yukgunja-tang and placebo groups. The herbal group showed significant improvement in nausea (-55%) and appetite (+42%).

Key Conclusion

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

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Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al.

Brain Imaging and Behavior (2024)

ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Herbal medicine modulates IBS at the central level of the brain-gut axis.

View Source 2024
Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al. Brain Imaging and Behavior (2024)
ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Summary

Thirty IBS patients received Tongxieyao-fang for 8 weeks, with fMRI comparison of brain activity. Hyperactivity in the anterior cingulate cortex (ACC) and insula decreased, and IBS-SSS showed concurrent improvement.

Key Conclusion

Herbal medicine modulates IBS at the central level of the brain-gut axis.

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