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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 55 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Wellness / Restoration

Therapeutic Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Randomized Controlled Trial

Kim JH, Park SH, Lee JY, et al.

Journal of Korean Medicine (2023)

42% Fatigue reduction
35% NK cell activity increase
8 weeks Treatment duration

Bojungikgi-tang shows significant improvement effects on both subjective fatigue and objective immune indicators in chronic fatigue syndrome patients, providing scientific evidence for tonifying treatment.

View Source 2023
RCT Wellness / Restoration

Therapeutic Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Randomized Controlled Trial

Kim JH, Park SH, Lee JY, et al. Journal of Korean Medicine (2023)
42% Fatigue reduction
35% NK cell activity increase
8 weeks Treatment duration

Summary

A randomized controlled trial comparing 8 weeks of Bojungikgi-tang versus placebo in 96 patients with chronic fatigue syndrome. The Bojungikgi-tang group showed an average 42% reduction in Fatigue Severity Scale (FSS), significant improvement compared to placebo group (18% reduction). NK cell activity increased by 35%, also confirming immune function enhancement effects.

Key Conclusion

Bojungikgi-tang shows significant improvement effects on both subjective fatigue and objective immune indicators in chronic fatigue syndrome patients, providing scientific evidence for tonifying treatment.

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Systematic Review Wellness / Restoration

Systematic Review of Anti-Fatigue and Immune-Enhancing Effects of Deer Antler Extract

Lee MK, Choi SJ, Kim HJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

28% Endurance improvement
15 studies Analyzed studies
40s+ Maximum effect age

Deer antler extract shows significant effects on physical endurance improvement and immune function enhancement, and is scientifically valid as a tonifying treatment material for middle-aged and older adults.

View Source 2022
Systematic Review Wellness / Restoration

Systematic Review of Anti-Fatigue and Immune-Enhancing Effects of Deer Antler Extract

Lee MK, Choi SJ, Kim HJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
28% Endurance improvement
15 studies Analyzed studies
40s+ Maximum effect age

Summary

Fifteen clinical studies examining anti-fatigue and immune-enhancing effects of deer antler extract were systematically analyzed. Meta-analysis showed an average 28% increase in physical endurance and significantly elevated IgG antibody levels in the deer antler group. Effects were particularly pronounced in the age group of 40s and older.

Key Conclusion

Deer antler extract shows significant effects on physical endurance improvement and immune function enhancement, and is scientifically valid as a tonifying treatment material for middle-aged and older adults.

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Cohort Study Wellness / Restoration

Postoperative Recovery Promotion Effect of Combined Herbal Medicine: A Prospective Cohort Study

Yoon SH, Kang BK, Han CH, et al.

Integrative Medicine Research (2023)

2.1 days Discharge duration reduction
45% Appetite recovery speed improvement
210 patients Study population

Combined herbal medicine treatment after surgery contributes to appetite recovery, normalization of bowel function, and shortened hospitalization, having value as an integrative medical recovery strategy.

View Source 2023
Cohort Study Wellness / Restoration

Postoperative Recovery Promotion Effect of Combined Herbal Medicine: A Prospective Cohort Study

Yoon SH, Kang BK, Han CH, et al. Integrative Medicine Research (2023)
2.1 days Discharge duration reduction
45% Appetite recovery speed improvement
210 patients Study population

Summary

A cohort study comparing recovery speed between combined herbal medicine administration and general recovery groups in 210 patients after major surgery. In the herbal medicine combination group, mean time to appetite recovery was 3.2 days (general group 5.8 days), with average reduction of 2.1 days to discharge.

Key Conclusion

Combined herbal medicine treatment after surgery contributes to appetite recovery, normalization of bowel function, and shortened hospitalization, having value as an integrative medical recovery strategy.

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Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Korean Medicine Tonifying Prescriptions

Kim TH, Hong JY, Leem JT, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

35% NK cell activity increase
1,450 patients Total participants

Korean medicine tonifying prescriptions have significant effects on immune function enhancement and are useful for patients with chronic fatigue and immune decline.

View Source 2023
Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Korean Medicine Tonifying Prescriptions

Kim TH, Hong JY, Leem JT, et al. Evidence-Based Complementary and Alternative Medicine (2023)
35% NK cell activity increase
1,450 patients Total participants

Summary

A systematic review evaluating immune-enhancing effects of Korean medicine tonifying prescriptions (Sipjeondaebo-tang, Bojungikgi-tang, etc.). A total of 20 studies were analyzed, with significant effects confirmed on NK cell activity and cytokine level improvement.

Key Conclusion

Korean medicine tonifying prescriptions have significant effects on immune function enhancement and are useful for patients with chronic fatigue and immune decline.

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RCT Wellness / Restoration

Randomized Controlled Trial of Deer Antler Combination Prescription for Physical Strength Enhancement

Park SU, Lim JA, Song HJ, et al.

Journal of Ethnopharmacology (2024)

42% Fatigue improvement rate
90 patients Participants

Deer antler combination prescription is an effective Korean medicine tonifying method for physical strength enhancement and fatigue recovery in chronic fatigue patients.

View Source 2024
RCT Wellness / Restoration

Randomized Controlled Trial of Deer Antler Combination Prescription for Physical Strength Enhancement

Park SU, Lim JA, Song HJ, et al. Journal of Ethnopharmacology (2024)
42% Fatigue improvement rate
90 patients Participants

Summary

A randomized controlled trial comparing deer antler combination prescription and placebo in 90 adults complaining of chronic fatigue. After 8 weeks of administration, physical strength indicators (grip strength, VO2max) and fatigue levels significantly improved.

Key Conclusion

Deer antler combination prescription is an effective Korean medicine tonifying method for physical strength enhancement and fatigue recovery in chronic fatigue patients.

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Cohort Study Wellness / Restoration

Improvement Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Prospective Cohort Study

Han CH, Seo BK, Choi JB, et al.

Journal of Korean Medicine (2024)

78% Fatigue improvement rate
120 patients Participants

Bojungikgi-tang is effective for comprehensive health improvement in chronic fatigue syndrome patients.

View Source 2024
Cohort Study Wellness / Restoration

Improvement Effect of Bojungikgi-tang for Chronic Fatigue Syndrome: A Prospective Cohort Study

Han CH, Seo BK, Choi JB, et al. Journal of Korean Medicine (2024)
78% Fatigue improvement rate
120 patients Participants

Summary

A prospective cohort study administering Bojungikgi-tang for 12 weeks and following 120 patients with chronic fatigue syndrome. Significant improvements appeared in fatigue level, quality of life, and vitality indicators.

Key Conclusion

Bojungikgi-tang is effective for comprehensive health improvement in chronic fatigue syndrome patients.

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Before-After Wellness / Restoration

Effect of Sasang Constitution-Tailored Tonifying Prescription: A Pre-Post Comparison Study

Choi AR, Im JG, Lee SJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

86% Subjective health improvement rate
80 patients Participants

Tonifying prescription tailored to Sasang constitution shows superior health promotion effects compared to general tonifying medicine.

View Source 2022
Before-After Wellness / Restoration

Effect of Sasang Constitution-Tailored Tonifying Prescription: A Pre-Post Comparison Study

Choi AR, Im JG, Lee SJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
86% Subjective health improvement rate
80 patients Participants

Summary

Sasang constitution-tailored tonifying medicine was prescribed for 8 weeks to 80 adults visiting for health promotion, with pre-post comparison. The constitution-tailored prescription group showed greater improvements in fatigue and immune indicators compared to non-constitution prescription group.

Key Conclusion

Tonifying prescription tailored to Sasang constitution shows superior health promotion effects compared to general tonifying medicine.

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Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Tonic Herbal Prescriptions

Song MY, Lim BM, Jung HJ, et al.

Evidence-Based Complementary and Alternative Medicine (2022)

25 studies Included Studies
2,143 subjects Total Participants
Increased NK cell activity Immune Enhancement

Tonic herbal prescriptions provide evidence of enhancing both innate and adaptive immunity, with the development of standardized protocols required.

View Source 2022
Systematic Review Wellness / Restoration

Systematic Review of Immune-Enhancing Effects of Tonic Herbal Prescriptions

Song MY, Lim BM, Jung HJ, et al. Evidence-Based Complementary and Alternative Medicine (2022)
25 studies Included Studies
2,143 subjects Total Participants
Increased NK cell activity Immune Enhancement

Summary

A systematic analysis of 25 clinical studies investigating the immune-enhancing effects of tonic herbal prescriptions. NK cell activity, IgG levels, and lymphocyte subset changes were comprehensively evaluated.

Key Conclusion

Tonic herbal prescriptions provide evidence of enhancing both innate and adaptive immunity, with the development of standardized protocols required.

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Meta-Analysis Wellness / Restoration

Meta-Analysis of Tonic Herbal Medicine for Cancer-Related Fatigue

Hong JM, Kwon CY, Lee BH, et al.

Supportive Care in Cancer (2024)

19 RCTs Included Studies
1,567 subjects Total Participants
MD -1.89 BFI Mean Difference

Tonic herbal medicine has significant efficacy as a complementary treatment for cancer-related fatigue, with confirmed safety.

View Source 2024
Meta-Analysis Wellness / Restoration

Meta-Analysis of Tonic Herbal Medicine for Cancer-Related Fatigue

Hong JM, Kwon CY, Lee BH, et al. Supportive Care in Cancer (2024)
19 RCTs Included Studies
1,567 subjects Total Participants
MD -1.89 BFI Mean Difference

Summary

A meta-analysis of 19 randomized controlled trials investigating the effect of tonic herbal medicine on cancer-related fatigue. Brief Fatigue Inventory scores significantly decreased and quality of life improved.

Key Conclusion

Tonic herbal medicine has significant efficacy as a complementary treatment for cancer-related fatigue, with confirmed safety.

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Cohort Study Wellness / Restoration

Effect of Modified Bojungikgi-tang Prescription on Qi Deficiency in Soeumin Constitution: A Multicenter Cohort Study

Baik TH, Yun YJ, Kim LH, et al.

Journal of Korean Medicine (2022)

180 subjects Participants
Qi deficiency symptoms 53% reduction Constitutional Improvement
12 weeks Follow-up Period

Modified Bojungikgi-tang is an effective personalized prescription for constitutional improvement in Soeumin qi deficiency.

View Source 2022
Cohort Study Wellness / Restoration

Effect of Modified Bojungikgi-tang Prescription on Qi Deficiency in Soeumin Constitution: A Multicenter Cohort Study

Baik TH, Yun YJ, Kim LH, et al. Journal of Korean Medicine (2022)
180 subjects Participants
Qi deficiency symptoms 53% reduction Constitutional Improvement
12 weeks Follow-up Period

Summary

One hundred eighty patients diagnosed with Soeumin qi deficiency received modified Bojungikgi-tang and were followed for 12 weeks. The qi deficiency symptom scale, fatigue, and digestive function significantly improved.

Key Conclusion

Modified Bojungikgi-tang is an effective personalized prescription for constitutional improvement in Soeumin qi deficiency.

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Before-After Wellness / Restoration

Cytokine Profile Changes in Chronic Fatigue Syndrome Patients After Herbal Prescription

Son MJ, Ahn CB, Kim SJ, et al.

Cytokine (2023)

50 subjects Participants
TNF-α 33% reduction Inflammation Regulation
IL-10 45% increase Anti-Inflammatory Response

Personalized herbal prescriptions contribute to correcting immune imbalance in chronic fatigue syndrome.

View Source 2023
Before-After Wellness / Restoration

Cytokine Profile Changes in Chronic Fatigue Syndrome Patients After Herbal Prescription

Son MJ, Ahn CB, Kim SJ, et al. Cytokine (2023)
50 subjects Participants
TNF-α 33% reduction Inflammation Regulation
IL-10 45% increase Anti-Inflammatory Response

Summary

Fifty patients with chronic fatigue syndrome received pattern-differentiation-tailored herbal medicine, and serum cytokine concentrations before and after treatment were analyzed by multiplex assay. Pro-inflammatory cytokines (TNF-α, IL-6) decreased and anti-inflammatory IL-10 increased.

Key Conclusion

Personalized herbal prescriptions contribute to correcting immune imbalance in chronic fatigue syndrome.

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RCT Wellness / Restoration

Impact of Sipjeondaebo-tang on Fatigue and Quality of Life in Cancer Survivors: A Randomized Controlled Trial

Kim SH, Jang SB, Yun YJ, et al.

Cancer (2024)

42% Fatigue reduction rate
120 patients Participants
12 weeks Administration period

Sipjeondaebo-tang effectively reduces fatigue and improves quality of life in cancer survivors.

View Source 2024
RCT Wellness / Restoration

Impact of Sipjeondaebo-tang on Fatigue and Quality of Life in Cancer Survivors: A Randomized Controlled Trial

Kim SH, Jang SB, Yun YJ, et al. Cancer (2024)
42% Fatigue reduction rate
120 patients Participants
12 weeks Administration period

Summary

The effect of 12-week Sipjeondaebo-tang administration was evaluated in 120 cancer survivors complaining of cancer-related fatigue after completing anticancer treatment. BFI (Brief Fatigue Inventory) scores decreased by 42%, with significantly improved FACT-G quality of life scores.

Key Conclusion

Sipjeondaebo-tang effectively reduces fatigue and improves quality of life in cancer survivors.

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