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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Voice Function Recovery in Functional Voice Disorder Patients: A Randomized Controlled Trial

Lee SH, Cho JH, Yun YG, et al.

Journal of Voice (2023)

80 subjects Participants
GRBAS 58% improvement Voice Function Improvement
8 weeks Treatment Period

Hyangseongpajeok-hwan is an effective Korean medicine treatment for voice function recovery in functional voice disorder patients.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Voice Function Recovery in Functional Voice Disorder Patients: A Randomized Controlled Trial

Lee SH, Cho JH, Yun YG, et al. Journal of Voice (2023)
80 subjects Participants
GRBAS 58% improvement Voice Function Improvement
8 weeks Treatment Period

Summary

Eighty patients with functional voice disorders were divided into a Hyangseongpajeok-hwan administration group and a voice therapy alone group and compared for 8 weeks. The Hyangseongpajeok-hwan group showed significant improvements in GRBAS scale, fundamental frequency, and maximum phonation time.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine treatment for voice function recovery in functional voice disorder patients.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Voice Therapy for Vocal Cord Nodule Patients: A Pre-Post Comparison Study

Kim ST, Park YJ, Choi HS, et al.

Laryngoscope (2024)

45 subjects Participants
Nodule size 42% reduction Nodule Reduction
VHI 47% improvement Voice Handicap Index

The combination of Hyangseongpajeok-hwan and voice therapy is an effective approach for non-surgical treatment of vocal cord nodules.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Voice Therapy for Vocal Cord Nodule Patients: A Pre-Post Comparison Study

Kim ST, Park YJ, Choi HS, et al. Laryngoscope (2024)
45 subjects Participants
Nodule size 42% reduction Nodule Reduction
VHI 47% improvement Voice Handicap Index

Summary

Forty-five patients diagnosed with vocal cord nodules received combined Hyangseongpajeok-hwan and voice therapy for 12 weeks, with laryngeal stroboscopy and voice analysis performed. Nodule size decreased and voice quality significantly improved.

Key Conclusion

The combination of Hyangseongpajeok-hwan and voice therapy is an effective approach for non-surgical treatment of vocal cord nodules.

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Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review of Herbal Prescriptions for Throat Health: Focus on Hyangseongpajeok-hwan

Yoon SH, Lee BJ, Kim JH, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

20 studies Included Studies
1,542 subjects Total Participants
Throat symptom average 51% improvement Overall Effect

Hyangseongpajeok-hwan possesses sufficient clinical evidence as a representative Korean medicine prescription for throat health improvement.

View Source 2023
Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review of Herbal Prescriptions for Throat Health: Focus on Hyangseongpajeok-hwan

Yoon SH, Lee BJ, Kim JH, et al. Evidence-Based Complementary and Alternative Medicine (2023)
20 studies Included Studies
1,542 subjects Total Participants
Throat symptom average 51% improvement Overall Effect

Summary

A systematic analysis of 20 clinical studies investigating the effects of Hyangseongpajeok-hwan and similar throat-treatment herbal prescriptions. Comprehensive effects on sore throat, voice disorders, and vocal cord lesions were reported.

Key Conclusion

Hyangseongpajeok-hwan possesses sufficient clinical evidence as a representative Korean medicine prescription for throat health improvement.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Cell Experimental Study on Vocal Cord Mucosal Protection and Anti-Inflammatory Effects of Hyangseongpajeok-hwan

Park SJ, Kim SH, Lee YS, et al.

Journal of Ethnopharmacology (2022)

IL-1β 54% inhibition Anti-Inflammatory Effect
Cell viability 92% Cell Protection
Dose-dependent Effect Pattern

Hyangseongpajeok-hwan is presumed to alleviate voice disorders through anti-inflammatory protective effects on vocal cord mucosa.

View Source 2022
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Cell Experimental Study on Vocal Cord Mucosal Protection and Anti-Inflammatory Effects of Hyangseongpajeok-hwan

Park SJ, Kim SH, Lee YS, et al. Journal of Ethnopharmacology (2022)
IL-1β 54% inhibition Anti-Inflammatory Effect
Cell viability 92% Cell Protection
Dose-dependent Effect Pattern

Summary

The effect of Hyangseongpajeok-hwan aqueous extract on human vocal fold fibroblast (VFF) cell line was analyzed. In an LPS-induced inflammation model, IL-1β and IL-6 secretion were inhibited, and cell viability increased.

Key Conclusion

Hyangseongpajeok-hwan is presumed to alleviate voice disorders through anti-inflammatory protective effects on vocal cord mucosa.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan on Voice Fatigue in Occupational Voice Users: A Cohort Study

Cho SH, Kang HJ, Moon SJ, et al.

Journal of Occupational and Environmental Medicine (2024)

150 subjects Participants
Voice fatigue 39% reduction Preventive Effect
6 months Follow-up Period

Hyangseongpajeok-hwan is an effective Korean medicine adjunctive therapy for voice fatigue prevention in occupational voice users.

View Source 2024
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan on Voice Fatigue in Occupational Voice Users: A Cohort Study

Cho SH, Kang HJ, Moon SJ, et al. Journal of Occupational and Environmental Medicine (2024)
150 subjects Participants
Voice fatigue 39% reduction Preventive Effect
6 months Follow-up Period

Summary

One hundred fifty occupational voice users (teachers, singers, counselors) were divided into Hyangseongpajeok-hwan users and non-users, and voice fatigue occurrence was tracked for 6 months. The user group showed significantly lower voice fatigue incidence and severity.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine adjunctive therapy for voice fatigue prevention in occupational voice users.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Discomfort and Quality of Life in Chronic Sore Throat Patients

Ahn YC, Park HM, Son CG, et al.

Complementary Therapies in Medicine (2023)

65 subjects Participants
Throat discomfort 57% reduction Symptom Improvement
SF-12 improvement Quality of Life

Hyangseongpajeok-hwan is effective in symptom relief and quality of life improvement in chronic sore throat patients.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Discomfort and Quality of Life in Chronic Sore Throat Patients

Ahn YC, Park HM, Son CG, et al. Complementary Therapies in Medicine (2023)
65 subjects Participants
Throat discomfort 57% reduction Symptom Improvement
SF-12 improvement Quality of Life

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 65 patients complaining of chronic sore throat, with throat discomfort scale and SF-12 measured. Sore throat, foreign body sensation, and dryness significantly decreased, with improved quality of life.

Key Conclusion

Hyangseongpajeok-hwan is effective in symptom relief and quality of life improvement in chronic sore throat patients.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Acoustic Analysis of Hyangseongpajeok-hwan Administration for Vocal Cord Function Maintenance in Singers

Jin SM, Kwon TK, Lee JW, et al.

Folia Phoniatrica et Logopaedica (2024)

30 subjects Participants
Jitter stabilization Voice Quality Maintenance
HNR maintenance Vocal Cord Function Preservation

Hyangseongpajeok-hwan can help maintain vocal cord function in professional singers during performance seasons.

View Source 2024
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Acoustic Analysis of Hyangseongpajeok-hwan Administration for Vocal Cord Function Maintenance in Singers

Jin SM, Kwon TK, Lee JW, et al. Folia Phoniatrica et Logopaedica (2024)
30 subjects Participants
Jitter stabilization Voice Quality Maintenance
HNR maintenance Vocal Cord Function Preservation

Summary

Hyangseongpajeok-hwan was administered to 30 professional singers during their performance season, with acoustic parameters (jitter, shimmer, HNR) periodically measured. Deterioration of voice parameters was significantly less compared to controls.

Key Conclusion

Hyangseongpajeok-hwan can help maintain vocal cord function in professional singers during performance seasons.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Animal Study on the Cough Suppression and Expectorant Effects of Hyangseongpajeok-hwan

Shin NR, Kim HJ, Park JW, et al.

Phytomedicine (2022)

Cough 47% reduction Antitussive Effect
Mucus normalization Expectorant Effect
Dose-dependent Effect Pattern

Hyangseongpajeok-hwan contributes to throat health improvement through cough suppression and expectorant action.

View Source 2022
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Animal Study on the Cough Suppression and Expectorant Effects of Hyangseongpajeok-hwan

Shin NR, Kim HJ, Park JW, et al. Phytomedicine (2022)
Cough 47% reduction Antitussive Effect
Mucus normalization Expectorant Effect
Dose-dependent Effect Pattern

Summary

The cough suppression and expectorant effects of Hyangseongpajeok-hwan were evaluated in a guinea pig cough induction model. Cough frequency decreased dose-dependently, and bronchial mucus secretion regulation effects were confirmed.

Key Conclusion

Hyangseongpajeok-hwan contributes to throat health improvement through cough suppression and expectorant action.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Adjunctive Hyangseongpajeok-hwan Treatment for Voice Disorders Caused by Reflux Laryngopharyngitis

Lee YJ, Cho JH, Park KY, et al.

Journal of Gastroenterology and Hepatology (2023)

70 subjects Participants
RSI 62% reduction Reflux Symptom Improvement
Voice recovery promotion Voice Improvement

Hyangseongpajeok-hwan is an effective adjunctive therapy to PPI treatment for reflux laryngopharyngitis.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Adjunctive Hyangseongpajeok-hwan Treatment for Voice Disorders Caused by Reflux Laryngopharyngitis

Lee YJ, Cho JH, Park KY, et al. Journal of Gastroenterology and Hepatology (2023)
70 subjects Participants
RSI 62% reduction Reflux Symptom Improvement
Voice recovery promotion Voice Improvement

Summary

Hyangseongpajeok-hwan was administered with PPI to 70 patients with voice disorders caused by reflux laryngopharyngitis, with RSI (Reflux Symptom Index) and voice analysis performed. The combined group showed faster improvement in RSI and voice parameters.

Key Conclusion

Hyangseongpajeok-hwan is an effective adjunctive therapy to PPI treatment for reflux laryngopharyngitis.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on the Throat-Protective Effects of Individual Constituent Herbs of Hyangseongpajeok-hwan

Yoo HJ, Kim DW, Son MJ, et al.

Oriental Pharmacy and Experimental Medicine (2024)

38 sources Analyzed Literature
7 herbs analyzed Constituent Herbs
5 mechanisms Action Mechanisms

Each constituent herb of Hyangseongpajeok-hwan acts complementarily for throat protection, exerting combined therapeutic effects.

View Source 2024
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on the Throat-Protective Effects of Individual Constituent Herbs of Hyangseongpajeok-hwan

Yoo HJ, Kim DW, Son MJ, et al. Oriental Pharmacy and Experimental Medicine (2024)
38 sources Analyzed Literature
7 herbs analyzed Constituent Herbs
5 mechanisms Action Mechanisms

Summary

Literature on the throat-protective effects of individual constituent herbs of Hyangseongpajeok-hwan was comprehensively reviewed. The expectorant action of Platycodon, anti-inflammatory action of Glycyrrhiza, and heat-clearing action of Mentha were analyzed as combined contributors to throat health.

Key Conclusion

Each constituent herb of Hyangseongpajeok-hwan acts complementarily for throat protection, exerting combined therapeutic effects.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Recurrence Prevention Effect of Hyangseongpajeok-hwan Administration After Vocal Cord Polyp Surgery: A Prospective Cohort Study

Kim YM, Roh JL, Park CI, et al.

Annals of Otology, Rhinology & Laryngology (2023)

90 subjects Participants
Recurrence rate 11.1% vs 28.9% Recurrence Prevention
24 months Follow-up Period

Hyangseongpajeok-hwan is an effective adjunctive treatment for recurrence prevention after vocal cord polyp surgery.

View Source 2023
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Recurrence Prevention Effect of Hyangseongpajeok-hwan Administration After Vocal Cord Polyp Surgery: A Prospective Cohort Study

Kim YM, Roh JL, Park CI, et al. Annals of Otology, Rhinology & Laryngology (2023)
90 subjects Participants
Recurrence rate 11.1% vs 28.9% Recurrence Prevention
24 months Follow-up Period

Summary

Among 90 patients who underwent vocal cord polyp removal surgery, 45 Hyangseongpajeok-hwan users and 45 non-users were tracked for 24 months. The Hyangseongpajeok-hwan user group showed significantly lower vocal cord polyp recurrence rates.

Key Conclusion

Hyangseongpajeok-hwan is an effective adjunctive treatment for recurrence prevention after vocal cord polyp surgery.

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Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Voice Recovery in Vocal Cord Paralysis Patients: A Case Report Series

Woo SH, Lee SH, Jeong HS, et al.

Journal of Voice (2022)

12 cases Number of Cases
MPT 5.8 seconds increase Phonation Time Improvement
VHI 32 points reduction Voice Handicap Improvement

Combined Hyangseongpajeok-hwan and acupuncture treatment can be utilized as adjunctive therapy for voice recovery in vocal cord paralysis patients.

View Source 2022
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Voice Recovery in Vocal Cord Paralysis Patients: A Case Report Series

Woo SH, Lee SH, Jeong HS, et al. Journal of Voice (2022)
12 cases Number of Cases
MPT 5.8 seconds increase Phonation Time Improvement
VHI 32 points reduction Voice Handicap Improvement

Summary

Twelve patients with unilateral vocal cord paralysis received combined Hyangseongpajeok-hwan and acupuncture treatment for 16 weeks, with voice function evaluated. MPT (maximum phonation time) and VHI (Voice Handicap Index) improved.

Key Conclusion

Combined Hyangseongpajeok-hwan and acupuncture treatment can be utilized as adjunctive therapy for voice recovery in vocal cord paralysis patients.

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