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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Total 93 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al.

Alzheimers Research & Therapy (2023)

25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

View Source 2023
Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al. Alzheimers Research & Therapy (2023)
25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

Summary

Twenty-five studies evaluating the neuroprotective effect of dementia prevention herbal medicines (Jogudeung-san, Danggwijakyak-san, etc.) were systematically reviewed. Herbal medicine showed significant effects on amyloid beta accumulation inhibition and hippocampal neuron protection.

Key Conclusion

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

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Before-After Neurological Disorders

Effect of Banhabaekchulcheonma-tang for Residual Dizziness in BPPV: A Pre-Post Comparison Study

Gu BM, Seol IC, Kim YS, et al.

Journal of Vestibular Research (2023)

52% DHI Reduction Rate
74% Dizziness Resolution
54 subjects Participants

Banhabaekchulcheonma-tang is effective for rapid resolution of residual dizziness after BPPV canalith repositioning.

View Source 2023
Before-After Neurological Disorders

Effect of Banhabaekchulcheonma-tang for Residual Dizziness in BPPV: A Pre-Post Comparison Study

Gu BM, Seol IC, Kim YS, et al. Journal of Vestibular Research (2023)
52% DHI Reduction Rate
74% Dizziness Resolution
54 subjects Participants

Summary

Fifty-four BPPV patients with residual dizziness persisting more than 2 weeks after canalith repositioning received Banhabaekchulcheonma-tang for 4 weeks. DHI scores decreased by an average of 52%, with complete residual dizziness resolution rate reaching 74%. Gait stability (TUG) also improved significantly.

Key Conclusion

Banhabaekchulcheonma-tang is effective for rapid resolution of residual dizziness after BPPV canalith repositioning.

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RCT Neurological Disorders

Effect of Combined Jinmu-tang and Vestibular Rehabilitation for Geriatric Vertigo: A Randomized Controlled Trial

Sung WS, Hong JW, Park SH, et al.

Geriatrics & Gerontology International (2024)

56% DHI Reduction Rate
108 subjects Participants
8 weeks Treatment Period

Adjunctive Jinmu-tang enhances vestibular rehabilitation effects in geriatric vertigo and reduces fall risk.

View Source 2024
RCT Neurological Disorders

Effect of Combined Jinmu-tang and Vestibular Rehabilitation for Geriatric Vertigo: A Randomized Controlled Trial

Sung WS, Hong JW, Park SH, et al. Geriatrics & Gerontology International (2024)
56% DHI Reduction Rate
108 subjects Participants
8 weeks Treatment Period

Summary

One hundred eight patients aged 65 or older with chronic vertigo were assigned to vestibular rehabilitation monotherapy or rehabilitation plus Jinmu-tang combination groups for 8 weeks of treatment. The combination group demonstrated a 56% reduction in DHI, significantly superior to monotherapy (38%), with greater improvement also in fall fear (FES-I).

Key Conclusion

Adjunctive Jinmu-tang enhances vestibular rehabilitation effects in geriatric vertigo and reduces fall risk.

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RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al.

Trigeminal Neuralgia Research (2024)

48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.

View Source 2024
RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Cheonmaguodeung-eum) for Trigeminal Neuralgia

Cha YR, Woo HS, Nam DH, et al. Trigeminal Neuralgia Research (2024)
48% Attacks↓
55 subjects Participants
Side effects↓ Safety

Summary

Fifty-five patients with trigeminal neuralgia were compared between Cheonmaguodeung-eum and carbamazepine groups for 8 weeks. The herbal medicine group showed significantly fewer side effects while decreasing pain attacks (-48%).

Key Conclusion

Cheonmaguodeung-eum is an alternative treatment for trigeminal neuralgia with fewer drug side effects.

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Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al.

Autonomic Neuroscience (2023)

16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

View Source 2023
Narrative Review Neurological Disorders

Narrative Review of Herbal Medicine (Banhahubak-tang) for Autonomic Dysfunction

Han SJ, Kim DH, Lee JA, et al. Autonomic Neuroscience (2023)
16 sources Reviewed Literature
HRV↑ Autonomic Regulation
Multiple symptoms Integrated Effect

Summary

Sixteen articles on the effect of Banhahubak-tang for autonomic dysfunction were reviewed. Banhahubak-tang showed multifaceted effects on HRV improvement and gastrointestinal, cardiovascular, and psychiatric symptoms.

Key Conclusion

Banhahubak-tang is an integrated Korean medicine treatment for multiple symptoms of autonomic dysfunction.

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RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al.

Clinical Autonomic Research (2023)

38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

View Source 2023
RCT Neurological Disorders

Randomized Controlled Trial of Herbal Medicine (Bojungikgi-tang) for Orthostatic Hypotension

Lee JY, Kwon CY, Shin HK, et al. Clinical Autonomic Research (2023)
38% BP variation↓
55 subjects Participants
Dizziness↓ Symptom Improvement

Summary

Fifty-five patients with orthostatic hypotension were compared between Bojungikgi-tang and placebo groups for 8 weeks. The herbal medicine group showed 38% improvement in systolic blood pressure drop on standing and reduction in dizziness.

Key Conclusion

Bojungikgi-tang is effective for blood pressure regulation and dizziness relief in orthostatic hypotension.

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Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al.

Journal of Korean Medicine (2023)

180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

View Source 2023
Cohort Study Neurological Disorders

Differences in Treatment Response by Sasang Constitution-Specific Herbal Medicine for Headache: A Cohort Study

Moon PD, Kang BK, Cho WS, et al. Journal of Korean Medicine (2023)
180 subjects Participants
28% Additional Improvement
Constitution customization Personalized Treatment

Summary

One hundred eighty patients with headache were followed for 12 weeks, divided into Sasang constitution-specific customized herbal medicine and standard herbal medicine groups. The customized group showed 28% additional improvement in HIT-6 headache impact scores.

Key Conclusion

Sasang constitution-specific customized herbal medicine improves treatment response for headache.

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Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al.

Neurobiology of Aging (2024)

Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

View Source 2024
Before-After Neurological Disorders

Hippocampal Volume Changes with Herbal Medicine (Jogudeung-san) for Mild Cognitive Impairment: A Pre-Post Comparison

Kang YH, Moon SJ, Cho WS, et al. Neurobiology of Aging (2024)
Hippocampal protection Atrophy Suppression
35 subjects Participants
MoCA↑ Cognition↑

Summary

Jogudeung-san was administered for 24 weeks to 35 elderly patients with mild cognitive impairment, and hippocampal volume was compared by MRI. Hippocampal volume reduction was significantly attenuated compared with the control group, and MoCA improved.

Key Conclusion

Jogudeung-san shows neuroprotective effects of suppressing hippocampal atrophy in mild cognitive impairment.

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Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al.

Pain Medicine (2023)

8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

View Source 2023
Case Study Neurological Disorders

Case Report of Herbal Medicine (Modified Samul-tang) for Paresthesia (Burning Sensation)

Kim GH, Cho WS, Park HJ, et al. Pain Medicine (2023)
8 cases Number of Cases
70%↓ Burning Sensation Reduction
Sleep↑ Additional Effect

Summary

A case report of modified Samul-tang administration for 12 weeks in 8 patients with unexplained limb burning sensation. Burning sensation decreased by more than 70% in 6 patients, with sleep improvement.

Key Conclusion

Modified Samul-tang may be effective for Korean medicine management of paresthesia (burning sensation).

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Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al.

Stroke (2024)

MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

View Source 2024
Before-After Neurological Disorders

Pre-Post Comparison Study of Herbal Medicine (Cheongsim-Yeonja-eum) for Post-Stroke Cognitive Impairment

Kwon CY, Song JH, Lee DH, et al. Stroke (2024)
MoCA +4.2 Cognition↑
40 subjects Participants
TMT↑ Executive Function

Summary

Cheongsim-Yeonja-eum was administered for 16 weeks to 40 patients with post-stroke cognitive impairment. MoCA (+4.2 points) and Trail Making Test significantly improved.

Key Conclusion

Cheongsim-Yeonja-eum is effective for recovery from post-stroke cognitive impairment.

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RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al.

Muscle & Nerve (2023)

48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

View Source 2023
RCT Neurological Disorders

Randomized Controlled Trial of Combined Herbal Medicine and Acupuncture for Carpal Tunnel Syndrome

Kim TH, Song MY, Park CW, et al. Muscle & Nerve (2023)
48% BQ↓
65 subjects Participants
Conduction↑ Nerve Improvement

Summary

Sixty-five patients with carpal tunnel syndrome were compared between herbal medicine + acupuncture and splint groups for 8 weeks. The Korean medicine treatment group showed significantly greater improvements in BQ symptom scores (-48%) and median nerve conduction.

Key Conclusion

Combined herbal medicine and acupuncture is superior to splinting for carpal tunnel syndrome.

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Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al.

Headache (2024)

55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

View Source 2024
Cohort Study Neurological Disorders

Preventive Effect of Herbal Medicine for Chronic Headache: A Cohort Study

Noh HM, Ahn YJ, Cho HJ, et al. Headache (2024)
55% Headache days↓
100 subjects Participants
Medication overuse↓ Dose Reduction Effect

Summary

One hundred patients with chronic headache were followed for 24 weeks, divided into herbal medicine (Cheongung-Dajo-san) and non-administration groups. The herbal medicine group showed 55% reduction in monthly headache days and decreased acute medication overuse.

Key Conclusion

Cheongung-Dajo-san is effective for long-term preventive treatment of chronic headache.

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