금맥한의원
Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

📅 Book Appointment 📋 Geummaek Herbal Medicine 💬 Reviews 📝 Health Columns
Research Papers
🔍

Total 91 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al.

Inflammatory Bowel Diseases (2023)

16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

View Source 2023
Narrative Review Digestive Disorders

Mucosal Healing Effect of Herbal Medicine for Crohn's Disease: A Narrative Review

Ryu BH, Kim KH, Song MY, et al. Inflammatory Bowel Diseases (2023)
16 papers Reviewed Papers
Mucosal healing↑ Main Effect
IL-6↓ Anti-inflammatory

Summary

Sixteen articles on herbal medicine treatment (Banhasasim-tang, Bojungikgi-tang, etc.) for Crohn's disease were reviewed. Herbal medicine showed effects in promoting intestinal mucosal healing and reducing inflammatory cytokines.

Key Conclusion

Herbal medicine is a promising adjunctive treatment supporting mucosal healing in Crohn's disease.

View Full Paper
RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al.

Digestive Diseases and Sciences (2024)

52% Heartburn↓
48% Reflux↓
80 subjects Participants

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

View Source 2024
RCT Digestive Disorders

Gastric Acid Suppression Effect of Osuyu-tang for Hyperacidity: A Randomized Controlled Trial

Kwon OJ, Seo YJ, Han DH, et al. Digestive Diseases and Sciences (2024)
52% Heartburn↓
48% Reflux↓
80 subjects Participants

Summary

Eighty patients with hyperacidity symptoms were compared over 6 weeks between Osuyu-tang and antacid groups. The herbal group showed equivalent improvement in heartburn (-52%) and acid reflux (-48%) compared to antacids.

Key Conclusion

Osuyu-tang is an effective herbal treatment for hyperacidity symptoms.

View Full Paper
Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al.

Acupuncture in Medicine (2023)

14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

View Source 2023
Meta-Analysis Digestive Disorders

Meta-analysis of Combined Acupuncture and Moxibustion for Chronic Diarrhea

Noh HM, Kang SH, Yoon JY, et al. Acupuncture in Medicine (2023)
14 RCTs Analyzed RCTs
RR 1.52 Stool Normalization
Acupuncture+Moxa Combination Effect

Summary

Fourteen RCTs evaluating the effect of combined acupuncture plus moxibustion on chronic diarrhea were meta-analyzed. The combined group demonstrated significant effects on stool frequency normalization (RR: 1.52) and Bristol Scale improvement.

Key Conclusion

Combined acupuncture and moxibustion is effective in normalizing stool frequency and form in chronic diarrhea.

View Full Paper
RCT Digestive Disorders

Acupuncture Treatment for Stress-Related Irritable Bowel Syndrome with Anxiety: A Randomized Controlled Trial

Park BS, Kang JH, Lee EH, et al.

Neurogastroenterology & Motility (2023)

48% IBS symptoms↓
42% Anxiety↓
Gut-brain axis Mechanism

Acupuncture treatment simultaneously improves irritable bowel syndrome and accompanying anxiety through the gut-brain axis.

View Source 2023
RCT Digestive Disorders

Acupuncture Treatment for Stress-Related Irritable Bowel Syndrome with Anxiety: A Randomized Controlled Trial

Park BS, Kang JH, Lee EH, et al. Neurogastroenterology & Motility (2023)
48% IBS symptoms↓
42% Anxiety↓
Gut-brain axis Mechanism

Summary

Eighty-five patients with comorbid IBS and anxiety were divided into acupuncture and sham acupuncture groups and compared for 8 weeks. Both IBS-SSS (-48%) and GAD-7 (-42%) significantly improved in the acupuncture group.

Key Conclusion

Acupuncture treatment simultaneously improves irritable bowel syndrome and accompanying anxiety through the gut-brain axis.

View Full Paper
RCT Digestive Disorders

Effect of Herbal Medicine for Stress-Related Functional Dyspepsia: An RCT

Jin WY, Han SH, et al.

Digestive Diseases and Sciences (2024)

90 subjects Participants
63% Dyspepsia Improvement Rate
8 weeks Treatment Period

Sihosogan-san is an effective treatment for breaking the vicious cycle of stress and dyspepsia.

View Source 2024
RCT Digestive Disorders

Effect of Herbal Medicine for Stress-Related Functional Dyspepsia: An RCT

Jin WY, Han SH, et al. Digestive Diseases and Sciences (2024)
90 subjects Participants
63% Dyspepsia Improvement Rate
8 weeks Treatment Period

Summary

Ninety patients with stress-related functional dyspepsia were randomly assigned to Sihosogan-san and placebo groups and compared for 8 weeks. Dyspepsia symptoms and PSS scores simultaneously improved in the herbal medicine group.

Key Conclusion

Sihosogan-san is an effective treatment for breaking the vicious cycle of stress and dyspepsia.

View Full Paper
RCT Digestive Disorders

Gut Microbiota Changes and Therapeutic Effect of Constitution-Tailored Herbal Treatment for Chronic Constipation

Oh SJ, Kim JE, Park DI, et al.

Gut Microbes (2024)

70 subjects Participants
Bowel frequency 2.8-fold increase Defecation Improvement
Increased microbial diversity Gut Environment Improvement

Constitution-tailored herbal medicine can effectively treat chronic constipation by improving the gut microbial environment.

View Source 2024
RCT Digestive Disorders

Gut Microbiota Changes and Therapeutic Effect of Constitution-Tailored Herbal Treatment for Chronic Constipation

Oh SJ, Kim JE, Park DI, et al. Gut Microbes (2024)
70 subjects Participants
Bowel frequency 2.8-fold increase Defecation Improvement
Increased microbial diversity Gut Environment Improvement

Summary

Seventy patients with chronic constipation received constitution-tailored herbal medicine, and gut microbiota composition and bowel habits were observed for 8 weeks. Gut microbial diversity increased after herbal administration, and bowel movement frequency significantly increased.

Key Conclusion

Constitution-tailored herbal medicine can effectively treat chronic constipation by improving the gut microbial environment.

View Full Paper
RCT Digestive Disorders

Effect of Personalized Herbal Prescriptions on Glycemic Control in Type 2 Diabetes Prediabetic Patients

Kang SY, Yoo JH, Lee BJ, et al.

Complementary Therapies in Medicine (2024)

90 subjects Participants
HbA1c 0.4% reduction Glycemic Control
HOMA-IR 28% improvement Insulin Resistance

Constitution-based personalized herbal medicine is effective in improving glycemic control and insulin resistance in prediabetes.

View Source 2024
RCT Digestive Disorders

Effect of Personalized Herbal Prescriptions on Glycemic Control in Type 2 Diabetes Prediabetic Patients

Kang SY, Yoo JH, Lee BJ, et al. Complementary Therapies in Medicine (2024)
90 subjects Participants
HbA1c 0.4% reduction Glycemic Control
HOMA-IR 28% improvement Insulin Resistance

Summary

Ninety patients with prediabetes were divided into a personalized herbal medicine group and a lifestyle modification control group and observed for 16 weeks. Fasting glucose, HbA1c, and HOMA-IR significantly improved in the herbal group.

Key Conclusion

Constitution-based personalized herbal medicine is effective in improving glycemic control and insulin resistance in prediabetes.

View Full Paper
RCT Digestive Disorders

Effect of Personalized Herbal Treatment on Symptoms and Quality of Life in Irritable Bowel Syndrome (IBS) Patients

Sung JH, Park SJ, Chen L, et al.

Journal of Gastroenterology (2024)

120 subjects Participants
IBS-SSS 51% reduction Symptom Improvement
QoL 34% improvement Quality of Life Improvement

Personalized herbal medicine is as effective as standard Western medicine treatment in symptom relief and quality of life improvement for IBS.

View Source 2024
RCT Digestive Disorders

Effect of Personalized Herbal Treatment on Symptoms and Quality of Life in Irritable Bowel Syndrome (IBS) Patients

Sung JH, Park SJ, Chen L, et al. Journal of Gastroenterology (2024)
120 subjects Participants
IBS-SSS 51% reduction Symptom Improvement
QoL 34% improvement Quality of Life Improvement

Summary

One hundred twenty IBS patients were randomly assigned to a constitution-based personalized herbal medicine group or a standard Western medicine treatment group and treated for 8 weeks. The herbal group showed significant reductions in IBS-SSS scores and improvements in IBS-QoL scores.

Key Conclusion

Personalized herbal medicine is as effective as standard Western medicine treatment in symptom relief and quality of life improvement for IBS.

View Full Paper
Case Study Digestive Disorders

Effect of Personalized Herbal Medicine on Metabolic Syndrome in Taeeumin Constitution: A Case Report Series

Lee KS, Jung DY, Park EK, et al.

Journal of Alternative and Complementary Medicine (2022)

10 cases Number of Cases
Triglycerides 27% reduction Lipid Improvement
Waist circumference 4.3cm reduction Abdominal Obesity Improvement

Taeeumin-tailored herbal medicine showed pronounced effects particularly in improving triglycerides and waist circumference among metabolic syndrome components.

View Source 2022
Case Study Digestive Disorders

Effect of Personalized Herbal Medicine on Metabolic Syndrome in Taeeumin Constitution: A Case Report Series

Lee KS, Jung DY, Park EK, et al. Journal of Alternative and Complementary Medicine (2022)
10 cases Number of Cases
Triglycerides 27% reduction Lipid Improvement
Waist circumference 4.3cm reduction Abdominal Obesity Improvement

Summary

Ten patients with metabolic syndrome diagnosed as Taeeumin constitution received constitution-tailored herbal medicine for 16 weeks, and changes in metabolic syndrome components (blood pressure, blood glucose, triglycerides, HDL, waist circumference) were observed.

Key Conclusion

Taeeumin-tailored herbal medicine showed pronounced effects particularly in improving triglycerides and waist circumference among metabolic syndrome components.

View Full Paper
RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

52% Symptom Improvement Rate
90 subjects Number of Participants

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

View Source 2023
RCT Digestive Disorders

Effect of Acupuncture on Functional Dyspepsia: A Randomized Controlled Trial

Kim JH, Lee TY, Park YC, et al. Evidence-Based Complementary and Alternative Medicine (2023)
52% Symptom Improvement Rate
90 subjects Number of Participants

Summary

Ninety patients with functional dyspepsia (Rome IV criteria) were divided into an acupuncture treatment group and a sham acupuncture group and treated for 8 weeks. The acupuncture treatment group showed a 52% improvement in dyspepsia symptom scores (NDI), demonstrating a significant difference from the sham group (21%).

Key Conclusion

Acupuncture is effective for symptom improvement in functional dyspepsia and shows significant superiority compared to sham treatment.

View Full Paper
Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al.

BMC Complementary Medicine and Therapies (2024)

OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

View Source 2024
Meta-Analysis Digestive Disorders

Systematic Review and Meta-Analysis of Herbal Medicine Treatment for Irritable Bowel Syndrome

Choi JY, Ko SJ, Park JW, et al. BMC Complementary Medicine and Therapies (2024)
OR 2.56 Odds Ratio
21 studies Number of Reviewed RCTs

Summary

The effect of herbal medicine treatment for irritable bowel syndrome (IBS) was meta-analyzed across 21 RCTs. The overall symptom improvement rate of the herbal medicine group was significantly higher than the Western medicine control group at OR 2.56 (95% CI: 1.87-3.51).

Key Conclusion

Herbal medicine demonstrates significant effects compared to Western medicine for IBS symptom improvement, with particularly pronounced effects in diarrhea-predominant and mixed types.

View Full Paper
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al.

Journal of Ethnopharmacology (2022)

79% Symptom Improvement Rate
70 subjects Number of Participants

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

View Source 2022
RCT Digestive Disorders

Treatment Effect of Banhasasim-tang for Reflux Esophagitis: A Randomized Controlled Trial

Lee SJ, Kim NK, Baek NI, et al. Journal of Ethnopharmacology (2022)
79% Symptom Improvement Rate
70 subjects Number of Participants

Summary

Seventy patients with reflux esophagitis (LA classification grades A-B) were divided into a Banhasasim-tang group and a PPI control group and treated for 8 weeks. The symptom improvement rate of the Banhasasim-tang group (79%) showed no statistically significant difference from the PPI group (83%).

Key Conclusion

Banhasasim-tang demonstrates effects similar to PPIs in mild-to-moderate reflux esophagitis and may serve as a safe alternative.

View Full Paper