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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan for Occupational Voice Disorders in Teachers: A Randomized Controlled Trial

Park JH, Son YI, Choi SH, et al.

Journal of Occupational Health (2024)

100 subjects Participants
Voice symptoms 54% improvement Symptom Relief
12 weeks Treatment Period

Hyangseongpajeok-hwan is an effective Korean medicine prescription for treating occupational voice disorders in teachers.

View Source 2024
RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan for Occupational Voice Disorders in Teachers: A Randomized Controlled Trial

Park JH, Son YI, Choi SH, et al. Journal of Occupational Health (2024)
100 subjects Participants
Voice symptoms 54% improvement Symptom Relief
12 weeks Treatment Period

Summary

One hundred teachers with occupational voice disorders were divided into a Hyangseongpajeok-hwan administration group and a vocal hygiene education control group and compared for 12 weeks. Voice-related symptoms and acoustic indicators significantly improved in the Hyangseongpajeok-hwan group.

Key Conclusion

Hyangseongpajeok-hwan is an effective Korean medicine prescription for treating occupational voice disorders in teachers.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Laryngoscopic Findings and Symptoms in Chronic Laryngitis Patients

Choi JO, Kim KM, Yoon TM, et al.

Auris Nasus Larynx (2023)

55 subjects Participants
Laryngeal inflammation 49% reduction Inflammation Improvement
Hoarseness 61% improvement Voice Recovery

Hyangseongpajeok-hwan is effective in alleviating inflammation and improving symptoms in chronic laryngitis.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Laryngoscopic Findings and Symptoms in Chronic Laryngitis Patients

Choi JO, Kim KM, Yoon TM, et al. Auris Nasus Larynx (2023)
55 subjects Participants
Laryngeal inflammation 49% reduction Inflammation Improvement
Hoarseness 61% improvement Voice Recovery

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 55 chronic laryngitis patients, with laryngoscopy and subjective symptom assessment performed. Laryngeal hyperemia and edema decreased, and sore throat and hoarseness improved.

Key Conclusion

Hyangseongpajeok-hwan is effective in alleviating inflammation and improving symptoms in chronic laryngitis.

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Meta-Analysis Hyangseongpajeokhwan (響聲破笛丸)

Meta-Analysis of Voice Disorder Treatment Effect of Combined Hyangseongpajeok-hwan and Vocal Training

Jung AR, Kim GH, Lee YW, et al.

Clinical Rehabilitation (2024)

15 studies Included Studies
1,124 subjects Total Participants
VHI MD -8.7 Voice Handicap Improvement

The combination of Hyangseongpajeok-hwan and vocal training demonstrates synergistic effects in voice disorder treatment.

View Source 2024
Meta-Analysis Hyangseongpajeokhwan (響聲破笛丸)

Meta-Analysis of Voice Disorder Treatment Effect of Combined Hyangseongpajeok-hwan and Vocal Training

Jung AR, Kim GH, Lee YW, et al. Clinical Rehabilitation (2024)
15 studies Included Studies
1,124 subjects Total Participants
VHI MD -8.7 Voice Handicap Improvement

Summary

A meta-analysis of 15 clinical studies analyzing the effect of combined Hyangseongpajeok-hwan and vocal training. Combined treatment showed significantly superior improvements in VHI, MPT, and jitter/shimmer compared to single treatment.

Key Conclusion

The combination of Hyangseongpajeok-hwan and vocal training demonstrates synergistic effects in voice disorder treatment.

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Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Antioxidant Component Analysis of Hyangseongpajeok-hwan and Its Inhibitory Effect on Vocal Cord Mucosal Oxidative Stress

Seo BI, Park JH, Lyu YS, et al.

Antioxidants (2023)

6 flavonoids Antioxidant Components
ROS 58% reduction Oxidative Stress Inhibition
GSH 43% increase Antioxidant Defense

The antioxidant components of Hyangseongpajeok-hwan contribute to protection of vocal cord mucosa from oxidative stress.

View Source 2023
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Antioxidant Component Analysis of Hyangseongpajeok-hwan and Its Inhibitory Effect on Vocal Cord Mucosal Oxidative Stress

Seo BI, Park JH, Lyu YS, et al. Antioxidants (2023)
6 flavonoids Antioxidant Components
ROS 58% reduction Oxidative Stress Inhibition
GSH 43% increase Antioxidant Defense

Summary

Major antioxidant components of Hyangseongpajeok-hwan were analyzed by HPLC, and the inhibitory effect on H2O2-induced oxidative stress was evaluated in vocal cord fibroblasts. Six flavonoids were identified, and intracellular ROS decreased dose-dependently.

Key Conclusion

The antioxidant components of Hyangseongpajeok-hwan contribute to protection of vocal cord mucosa from oxidative stress.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Recovery-Promoting Effect of Hyangseongpajeok-hwan for Voice Changes After Thyroid Surgery

Lee YC, Kim SW, Shin SC, et al.

Thyroid (2024)

40 subjects Participants
V-RQOL 38% improvement Voice-Related QoL
MPT 4.2 seconds increase Phonation Function Improvement

Hyangseongpajeok-hwan can be utilized as an adjunctive treatment promoting voice recovery after thyroid surgery.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Recovery-Promoting Effect of Hyangseongpajeok-hwan for Voice Changes After Thyroid Surgery

Lee YC, Kim SW, Shin SC, et al. Thyroid (2024)
40 subjects Participants
V-RQOL 38% improvement Voice-Related QoL
MPT 4.2 seconds increase Phonation Function Improvement

Summary

Hyangseongpajeok-hwan was administered for 12 weeks to 40 patients complaining of voice changes after thyroidectomy, with voice function tests performed. Fundamental frequency stability, MPT, and voice-related quality of life significantly improved.

Key Conclusion

Hyangseongpajeok-hwan can be utilized as an adjunctive treatment promoting voice recovery after thyroid surgery.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan for Recurrent Throat Infections in Children: A Randomized Controlled Pilot Trial

Yun YH, Ko SG, Kim AR, et al.

European Journal of Integrative Medicine (2023)

50 subjects Participants
Infection episodes 44% reduction Preventive Effect
6 months Observation Period

Hyangseongpajeok-hwan is a safe and effective complementary treatment for preventing recurrent throat infections in children.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Preventive Effect of Hyangseongpajeok-hwan for Recurrent Throat Infections in Children: A Randomized Controlled Pilot Trial

Yun YH, Ko SG, Kim AR, et al. European Journal of Integrative Medicine (2023)
50 subjects Participants
Infection episodes 44% reduction Preventive Effect
6 months Observation Period

Summary

Fifty children with recurrent throat infections were divided into a Hyangseongpajeok-hwan administration group and a placebo group and compared for throat infection episodes over 6 months. The administration group showed significant reduction in throat infection frequency.

Key Conclusion

Hyangseongpajeok-hwan is a safe and effective complementary treatment for preventing recurrent throat infections in children.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Exploratory Study on the Oral and Throat Microbiota Modulation Effect of Hyangseongpajeok-hwan

Han GJ, Song MY, Lee SJ, et al.

Microorganisms (2024)

35 subjects Participants
Pathogens 32% reduction Microbial Modulation
Beneficial bacteria increase Microbiota Improvement

Hyangseongpajeok-hwan may contribute to maintaining a healthy balance of throat microbiota.

View Source 2024
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Exploratory Study on the Oral and Throat Microbiota Modulation Effect of Hyangseongpajeok-hwan

Han GJ, Song MY, Lee SJ, et al. Microorganisms (2024)
35 subjects Participants
Pathogens 32% reduction Microbial Modulation
Beneficial bacteria increase Microbiota Improvement

Summary

Hyangseongpajeok-hwan was administered for 8 weeks to 35 patients with chronic throat discomfort, and throat microbiota changes were analyzed by 16S rRNA sequencing. Pathogenic bacterial proportions decreased and beneficial bacteria increased.

Key Conclusion

Hyangseongpajeok-hwan may contribute to maintaining a healthy balance of throat microbiota.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on Korean Medicine Treatment Strategies for Voice Recovery: Role of Hyangseongpajeok-hwan

Kim JH, Lee BJ, Shin HK, et al.

Journal of Korean Medicine (2022)

42 sources Analyzed Literature
4 pattern types Prescription Modifications
Combination strategies presented Clinical Recommendations

Hyangseongpajeok-hwan is a core prescription in Korean medicine treatment of voice disorders, with personalized modifications enhancing treatment effects.

View Source 2022
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Narrative Review on Korean Medicine Treatment Strategies for Voice Recovery: Role of Hyangseongpajeok-hwan

Kim JH, Lee BJ, Shin HK, et al. Journal of Korean Medicine (2022)
42 sources Analyzed Literature
4 pattern types Prescription Modifications
Combination strategies presented Clinical Recommendations

Summary

Korean medicine treatment strategies for voice disorders were narratively reviewed, and the role of Hyangseongpajeok-hwan and clinical utilization plans were analyzed. Prescription modification methods according to pattern differentiation and combination strategies with other treatment modalities were presented.

Key Conclusion

Hyangseongpajeok-hwan is a core prescription in Korean medicine treatment of voice disorders, with personalized modifications enhancing treatment effects.

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Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Post-Performance Voice Recovery Speed in Vocalists

Jang DY, Kim HT, Lee SJ, et al.

Journal of Voice (2024)

24 subjects Participants
Recovery time 48% shortened Recovery Promotion
Recovery within 24 hours Rapid Recovery

Hyangseongpajeok-hwan promotes post-performance voice recovery in vocalists, contributing to vocal cord health maintenance.

View Source 2024
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan Administration on Post-Performance Voice Recovery Speed in Vocalists

Jang DY, Kim HT, Lee SJ, et al. Journal of Voice (2024)
24 subjects Participants
Recovery time 48% shortened Recovery Promotion
Recovery within 24 hours Rapid Recovery

Summary

Voice recovery speed after a 2-hour performance was compared by Hyangseongpajeok-hwan use status in 24 professional vocalists. The Hyangseongpajeok-hwan user group showed voice parameters returning to baseline within 24 hours.

Key Conclusion

Hyangseongpajeok-hwan promotes post-performance voice recovery in vocalists, contributing to vocal cord health maintenance.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Symptom Relief in Laryngopharyngeal Reflux: A Double-Blind Trial

Cho GS, Park MW, Jung KY, et al.

Digestive Diseases and Sciences (2023)

88 subjects Participants
RSI 68% reduction Symptom Improvement
RFS 52% reduction Laryngeal Findings Improvement

The combination of Hyangseongpajeok-hwan and PPI demonstrates synergistic effects on throat symptom relief in laryngopharyngeal reflux.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of Hyangseongpajeok-hwan on Throat Symptom Relief in Laryngopharyngeal Reflux: A Double-Blind Trial

Cho GS, Park MW, Jung KY, et al. Digestive Diseases and Sciences (2023)
88 subjects Participants
RSI 68% reduction Symptom Improvement
RFS 52% reduction Laryngeal Findings Improvement

Summary

Eighty-eight patients with laryngopharyngeal reflux (LPR) were double-blindly assigned to Hyangseongpajeok-hwan+PPI combined and PPI alone groups and treated for 8 weeks. The combined group showed greater reductions in RSI and RFS (Reflux Finding Score).

Key Conclusion

The combination of Hyangseongpajeok-hwan and PPI demonstrates synergistic effects on throat symptom relief in laryngopharyngeal reflux.

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Case Study Hyangseongpajeokhwan (響聲破笛丸)

Long-Term Follow-Up Results of Conservative Hyangseongpajeok-hwan Treatment for Vocal Cord Leukoplakia Patients: A Case Series

Moon WJ, Kim YH, Hong HJ, et al.

Head & Neck (2024)

10 cases Number of Cases
80% disappearance/reduction Lesion Improvement
36 months Average Follow-up Period

Hyangseongpajeok-hwan-based conservative treatment is a safe management method for vocal cord leukoplakia, showing favorable outcomes even on long-term follow-up.

View Source 2024
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Long-Term Follow-Up Results of Conservative Hyangseongpajeok-hwan Treatment for Vocal Cord Leukoplakia Patients: A Case Series

Moon WJ, Kim YH, Hong HJ, et al. Head & Neck (2024)
10 cases Number of Cases
80% disappearance/reduction Lesion Improvement
36 months Average Follow-up Period

Summary

Conservative Korean medicine treatment centered on Hyangseongpajeok-hwan was administered to 10 patients with vocal cord leukoplakia and tracked for an average of 36 months. Leukoplakia disappeared or reduced in 8 patients, with no malignant transformation observed.

Key Conclusion

Hyangseongpajeok-hwan-based conservative treatment is a safe management method for vocal cord leukoplakia, showing favorable outcomes even on long-term follow-up.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al.

Laryngoscope (2023)

HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Experimental Study on the Vocal Cord Hyaluronic Acid Synthesis Promotion Effect of Hyangseongpajeok-hwan

Lim JY, Choi JN, Kim HS, et al. Laryngoscope (2023)
HAS2 2.3-fold increase Gene Expression
HA production 67% increase Hyaluronic Acid Promotion
p<0.01 Statistical Significance

Summary

Human vocal fold fibroblasts were treated with Hyangseongpajeok-hwan extract, and hyaluronic acid (HA) production and related gene expression were analyzed. HA synthase 2 expression increased, and HA production was significantly promoted.

Key Conclusion

Hyangseongpajeok-hwan can promote hyaluronic acid synthesis in vocal cord lamina propria, improving vocal cord vibration characteristics.

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