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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 33 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al.

Annals of Occupational and Environmental Medicine (2024)

80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

View Source 2024
RCT Hyangseongpajeokhwan (響聲破笛丸)

Effect of a Hyangseongpajeok-hwan Program for Voice Health Management of Call Center Workers

Lee JY, Choi HS, Park IS, et al. Annals of Occupational and Environmental Medicine (2024)
80 subjects Participants
Sick leave 52% reduction Industrial Effect
Voice self-evaluation improvement Subjective Improvement

Summary

Eighty call center workers were divided into a Hyangseongpajeok-hwan administration+vocal hygiene education group and a vocal hygiene education alone group and compared for 16 weeks. The Hyangseongpajeok-hwan group showed reduced voice-related sick leave days and improved voice self-evaluation scores.

Key Conclusion

Hyangseongpajeok-hwan can be effectively utilized in occupational voice health management programs for call center workers.

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Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al.

Acupuncture in Medicine (2023)

15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

View Source 2023
Case Study Hyangseongpajeokhwan (響聲破笛丸)

Effect of Combined Hyangseongpajeok-hwan and Acupuncture on Spasmodic Dysphonia: A Pilot Study

Chung PS, Kim HJ, Lee SJ, et al. Acupuncture in Medicine (2023)
15 subjects Participants
Voice breaks 38% reduction Symptom Improvement
Fluency improvement Voice Function Improvement

Summary

Combined Hyangseongpajeok-hwan and throat acupuncture was administered for 8 weeks to 15 patients with spasmodic dysphonia. Voice break frequency decreased and voice fluency improved.

Key Conclusion

Combined Hyangseongpajeok-hwan and acupuncture treatment is worth exploring as a complementary treatment option for spasmodic dysphonia.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al.

International Journal of Molecular Sciences (2025)

Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

View Source 2025
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Bronchial Epithelial Cell Protective Effect of Hyangseongpajeok-hwan and Implications for Throat Health

Park CS, Shin SY, Kim YD, et al. International Journal of Molecular Sciences (2025)
Apoptosis 45% inhibition Cell Protection
MUC5AC normalization Mucus Regulation
ZO-1 maintenance Mucosal Barrier Protection

Summary

The protective effect of Hyangseongpajeok-hwan extract on bronchial epithelial cells exposed to particulate matter (PM10) was evaluated. Apoptosis inhibition, mucus hypersecretion regulation, and tight junction protein expression maintenance effects were confirmed.

Key Conclusion

Hyangseongpajeok-hwan possesses protective effects on bronchial and throat mucosa from environmentally harmful factors.

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Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al.

Journal of Ethnopharmacology (2022)

4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

View Source 2022
Narrative Review Hyangseongpajeokhwan (響聲破笛丸)

Modern Reinterpretation of Korean Traditional Throat Treatment Prescriptions: Pharmacological Review of Hyangseongpajeok-hwan

Seo CS, Shin HK, Ha H, et al. Journal of Ethnopharmacology (2022)
4 pharmacological activities Validated Mechanisms
56 sources analyzed Number of Sources
Traditional-modern alignment Scientific Validation

Summary

Traditional prescription evidence and modern pharmacological research findings of Hyangseongpajeok-hwan were integrally analyzed. Four major pharmacological activities—anti-inflammatory, antioxidant, immunomodulatory, and mucosal protection—were confirmed to align with traditional efficacy descriptions.

Key Conclusion

The traditional efficacy of Hyangseongpajeok-hwan is scientifically supported by modern pharmacology, reaffirming its value as a standard Korean medicine prescription for throat diseases.

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Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al.

BMC Complementary Medicine and Therapies (2023)

120 subjects Participants
0 adverse events Safety
6 months Observation Period

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

View Source 2023
Cohort Study Hyangseongpajeokhwan (響聲破笛丸)

Safety Evaluation of Long-Term Hyangseongpajeok-hwan Use: A 6-Month Prospective Observational Study

Cho KH, Lee JA, Park SJ, et al. BMC Complementary Medicine and Therapies (2023)
120 subjects Participants
0 adverse events Safety
6 months Observation Period

Summary

Blood tests, liver function, and renal function indices were prospectively tracked in 120 patients who took Hyangseongpajeok-hwan for 6 months or longer. No clinically significant abnormal findings occurred.

Key Conclusion

Long-term 6-month use of Hyangseongpajeok-hwan is safe, with very low risk of serious adverse effects.

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Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al.

Environmental Health and Preventive Medicine (2025)

200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

View Source 2025
Cross-Sectional Hyangseongpajeokhwan (響聲破笛丸)

Cross-Sectional Survey on Throat Protective Effect of Hyangseongpajeok-hwan in High Particulate Matter Concentration Environments

Min BW, Kang SH, Choi YJ, et al. Environmental Health and Preventive Medicine (2025)
200 subjects Surveyed
Throat symptoms 36% reduction Protective Effect
p=0.008 Statistical Significance

Summary

Throat symptoms were comparatively investigated between Hyangseongpajeok-hwan users (100 subjects) and non-users (100 subjects) residing in high particulate matter areas. Throat symptoms such as sore throat, phlegm, and cough were significantly less in the user group.

Key Conclusion

Hyangseongpajeok-hwan can be utilized for preventing throat symptoms caused by environmental harmful factors such as particulate matter.

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RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan on Occupational Voice Disorders: A Randomized Controlled Trial

Kim SH, Yun YG, Lee JH, et al.

Journal of Voice (2023)

48% Voice Handicap Index Reduction
4.2 seconds Phonation Duration Extension
6 weeks Treatment Duration

Hyangseongpajeok-hwan demonstrates significant improvement in both subjective symptoms and objective vocal cord function in occupational voice disorders, proving effective for voice management in occupations involving heavy voice use.

View Source 2023
RCT Hyangseongpajeokhwan (響聲破笛丸)

Therapeutic Effect of Hyangseongpajeok-hwan on Occupational Voice Disorders: A Randomized Controlled Trial

Kim SH, Yun YG, Lee JH, et al. Journal of Voice (2023)
48% Voice Handicap Index Reduction
4.2 seconds Phonation Duration Extension
6 weeks Treatment Duration

Summary

A randomized controlled trial comparing 6 weeks of Hyangseongpajeok-hwan administration with placebo in 82 patients with occupational voice disorders (teachers, lecturers). The Hyangseongpajeok-hwan group showed an average 48% reduction in VHI (Voice Handicap Index), with significant improvement in vocal cord mucosal waves on laryngeal stroboscopy. Maximum phonation time (MPT) was extended by an average of 4.2 seconds.

Key Conclusion

Hyangseongpajeok-hwan demonstrates significant improvement in both subjective symptoms and objective vocal cord function in occupational voice disorders, proving effective for voice management in occupations involving heavy voice use.

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Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review on Vocal Cord Mucosal Protection and Voice Recovery Effects of Herbal Medicine

Chen YF, Wang SQ, Liu H, et al.

Complementary Therapies in Medicine (2022)

39% Voice Quality Improvement
16 studies Studies Analyzed
1,248 subjects Total Participants

Lung-moistening throat-soothing herbal medicine demonstrates significant effects in vocal cord mucosal protection and voice recovery and is recommended as a conservative treatment option for chronic laryngitis and early vocal cord nodules.

View Source 2022
Systematic Review Hyangseongpajeokhwan (響聲破笛丸)

Systematic Review on Vocal Cord Mucosal Protection and Voice Recovery Effects of Herbal Medicine

Chen YF, Wang SQ, Liu H, et al. Complementary Therapies in Medicine (2022)
39% Voice Quality Improvement
16 studies Studies Analyzed
1,248 subjects Total Participants

Summary

A systematic review of 16 clinical studies (total 1,248 subjects) evaluating the therapeutic effect of herbal medicine for vocal cord disorders and voice impairments. The lung-moistening throat-soothing herbal medicine group showed an average 39% improvement in voice quality index (GRBAS scale) compared to controls, with significantly higher reduction rates in vocal cord mucosal edema. Effects were particularly pronounced in chronic laryngitis and early vocal cord nodules.

Key Conclusion

Lung-moistening throat-soothing herbal medicine demonstrates significant effects in vocal cord mucosal protection and voice recovery and is recommended as a conservative treatment option for chronic laryngitis and early vocal cord nodules.

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Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Korean Medicine Combined Treatment for Vocal Fatigue Recovery in Singers and Vocalists: A Pre-Post Comparison Study

Park HJ, Cho SW, Lee MK, et al.

Logopedics Phoniatrics Vocology (2023)

52% Vocal Fatigue Reduction
3 semitones Vocal Range Expansion
46 subjects Study Participants

Korean medicine combined treatment is effective for vocal fatigue recovery and acoustic parameter normalization, scientifically validating its utility for voice management in professional vocalists.

View Source 2023
Before-After Hyangseongpajeokhwan (響聲破笛丸)

Effect of Korean Medicine Combined Treatment for Vocal Fatigue Recovery in Singers and Vocalists: A Pre-Post Comparison Study

Park HJ, Cho SW, Lee MK, et al. Logopedics Phoniatrics Vocology (2023)
52% Vocal Fatigue Reduction
3 semitones Vocal Range Expansion
46 subjects Study Participants

Summary

A pre-post comparison study combining Hyangseongpajeok-hwan and acupuncture for 4 weeks in 46 singers and vocalists complaining of post-performance vocal fatigue. Subjective vocal fatigue (VFI) decreased 52%, and acoustic analysis showed jitter and shimmer values returning to normal range. Vocal cord contact rate during high-pitch phonation improved, with vocal range expanding by an average of 3 semitones.

Key Conclusion

Korean medicine combined treatment is effective for vocal fatigue recovery and acoustic parameter normalization, scientifically validating its utility for voice management in professional vocalists.

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