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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 84 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al.

Journal of Ethnopharmacology (2024)

67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

View Source 2024
Systematic Review Men's Health / Urology

Effect of Herbal Medicine Treatment on Semen Parameter Improvement in Male Infertility Patients: A Systematic Review and Meta-Analysis

김동현, 이재훈, 박성민, et al. Journal of Ethnopharmacology (2024)
67.3% Sperm Motility Improvement Rate
1.8 fold Sperm Concentration Increase
p<0.001 Statistical Significance

Summary

A systematic review and meta-analysis analyzing the effect of herbal medicine treatment on semen parameter improvement in 1,247 male infertility patients. Twenty-three randomized controlled trials were included, and the herbal medicine administration group showed significant improvements in sperm concentration, motility, and normal morphology rate. The highest effect size was observed in Ojayeonjong-hwan-based prescriptions.

Key Conclusion

Herbal medicine treatment significantly improves semen parameters in male infertility patients and can contribute to pregnancy rate improvement when combined with assisted reproductive technology.

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Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al.

Phytomedicine (2023)

5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

View Source 2023
Systematic Review Men's Health / Urology

Effect of Epimedium-Based Herbal Medicine on Erectile Dysfunction (ED): A Systematic Review

신동혁, 문성환, 박준혁, et al. Phytomedicine (2023)
5.8 points IIEF-5 Improvement
18 studies Included Studies
p=0.002 Statistical Significance

Summary

A systematic review analyzing the effect of Epimedium (icariin-containing)-based herbal medicine in erectile dysfunction patients. Eighteen clinical trials were included, and the Epimedium extract administration group showed an average IIEF-5 score improvement of 5.8 points. PDE5 inhibitory activity and NO/cGMP pathway activation were confirmed as main mechanisms.

Key Conclusion

Epimedium-based herbal medicine is effective for mild-to-moderate erectile dysfunction and promotes corpus cavernosum relaxation through mechanisms similar to PDE5 inhibitors.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al.

The Journal of Sexual Medicine (2024)

7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

View Source 2024
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment for Sexual Dysfunction: A Meta-Analysis of Randomized Controlled Trials

이정환, 김도윤, 최병훈, et al. The Journal of Sexual Medicine (2024)
7.2 points IIEF Total Score Difference
892 subjects Total Subjects
14 RCTs Included RCTs

Summary

A meta-analysis of 14 randomized controlled trials including 892 male sexual dysfunction patients. The combined herbal medicine and acupuncture treatment group showed an average IIEF total score improvement 7.2 points higher than the control group, with significant differences confirmed in all subdomains of libido, erectile function, orgasm, and sexual satisfaction.

Key Conclusion

Combined herbal medicine and acupuncture treatment is effective for multidimensional improvement of male sexual dysfunction, with synergistic effects confirmed compared with single treatments.

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Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al.

Evidence-Based Complementary and Alternative Medicine (2024)

2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

View Source 2024
Cohort Study Men's Health / Urology

Effect of Deer Antler Combined Herbal Medicine on Testosterone and Libido Improvement in Libido Reduction: A Cohort Study

윤재석, 배한솔, 임성진, et al. Evidence-Based Complementary and Alternative Medicine (2024)
2.8 ng/dL Free Testosterone Increase
96 subjects Cohort Size
73.9% SDI Improvement Rate

Summary

A prospective cohort study analyzing the effect of deer antler combined herbal medicine in 96 men complaining of libido reduction. After 16 weeks of administration, serum free testosterone increased by an average of 2.8 ng/dL, and SDI (Sexual Desire Inventory) scores improved significantly. Response rates were highest in the 40-55 age group.

Key Conclusion

Deer antler combined herbal medicine significantly improves testosterone levels and libido-related indicators in libido reduction patients and is particularly effective for middle-aged and older men.

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Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al.

대한한의학회지 (2023)

38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

View Source 2023
Cross-Sectional Men's Health / Urology

Changes in AMS Scores with Combined Herbal Medicine and Moxibustion Treatment for Male Climacteric Syndrome (LOH): A Cross-Sectional Analysis

정현석, 김영태, 이상우, et al. 대한한의학회지 (2023)
38.9% AMS Score Reduction Rate
120 subjects Analysis Subjects
p<0.001 Statistical Significance

Summary

A cross-sectional analysis of medical records of 120 patients receiving Korean medicine treatment for male climacteric syndrome. AMS (Aging Males Symptoms) scores of the herbal medicine and moxibustion combined treatment group decreased from an average of 36.7 to 22.4, and significant improvements were confirmed in cardiovascular, somatic, and psychological subdomains.

Key Conclusion

Combined herbal medicine and moxibustion treatment effectively alleviates the multidimensional symptoms of male climacteric syndrome and enables clinically meaningful improvement without hormone replacement therapy.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al.

Urological Research (2023)

78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

View Source 2023
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Acupuncture Treatment on Stone Expulsion Promotion in Urolithiasis Patients: A Meta-Analysis

서민호, 곽영진, 이태규, et al. Urological Research (2023)
78.3% Stone Expulsion Rate
5.2 days Expulsion Time Shortened
634 subjects Total Subjects

Summary

A meta-analysis of 9 randomized controlled trials including 634 urolithiasis patients. The combined herbal medicine (modified Seokwi-san) and acupuncture treatment group showed a stone spontaneous expulsion rate of 78.3%, significantly higher than the control group (54.2%), with average expulsion time also shortened by 5.2 days.

Key Conclusion

Combined herbal medicine and acupuncture treatment significantly promotes spontaneous expulsion of urolithiasis 10 mm or less and is effective as adjunctive treatment for watchful waiting.

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RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al.

Journal of Ethnopharmacology (2024)

63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

View Source 2024
RCT Men's Health / Urology

Long-Term Effect of Herbal Medicine Treatment for Kidney Stone Recurrence Prevention: A Randomized Controlled Trial

김영호, 손재현, 박지민, et al. Journal of Ethnopharmacology (2024)
63.7% Recurrence Rate Reduction
128 subjects Number of Subjects
24 months Follow-up Period

Summary

A randomized controlled trial evaluating the long-term effect of herbal medicine (Geumjeoncho combined formula) for recurrence prevention after kidney stone removal. After 24 months of follow-up of 128 subjects, the herbal medicine group's stone recurrence rate was 12.5%, significantly lower than the control group (34.4%), and urinary calcium and oxalate excretion also decreased.

Key Conclusion

Geumjeoncho combined formula is effective for preventing kidney stone recurrence, and a mechanism regulating excretion of stone-forming substances in urine was confirmed.

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Case Study Men's Health / Urology

Effect of Herbal Medicine Treatment for Hydrocele: A Multicenter Case Report

임현준, 강유진, 배동식, et al.

대한한방내과학회지 (2023)

47.2% Hydrocele Reduction Rate
15 cases Number of Cases
13.3% 12-month Recurrence Rate

Herbal medicine treatment is effective as a non-surgical treatment alternative for mild-to-moderate hydrocele and shows lower recurrence rates compared with surgery.

View Source 2023
Case Study Men's Health / Urology

Effect of Herbal Medicine Treatment for Hydrocele: A Multicenter Case Report

임현준, 강유진, 배동식, et al. 대한한방내과학회지 (2023)
47.2% Hydrocele Reduction Rate
15 cases Number of Cases
13.3% 12-month Recurrence Rate

Summary

A multicenter case report on herbal medicine treatment in 15 patients with hydrocele. After 8-12 weeks of administration of modified Oryeong-san or modified Danggwijakyak-san at 3 Korean medicine hospitals, hydrocele volume on ultrasound decreased by an average of 47.2%, and complete resolution was confirmed in 4 patients. Recurrence rate at 12-month follow-up was 13.3%.

Key Conclusion

Herbal medicine treatment is effective as a non-surgical treatment alternative for mild-to-moderate hydrocele and shows lower recurrence rates compared with surgery.

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Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Electroacupuncture Treatment for Chronic Pelvic Pain Syndrome (CPPS): A Meta-Analysis

윤정호, 김상민, 이동현, et al.

Prostate (2024)

12.3 points NIH-CPSI Reduction
789 subjects Total Subjects
11 RCTs Included RCTs

Combined herbal medicine and electroacupuncture treatment is effective across all pain, urinary, and quality of life domains of chronic pelvic pain syndrome and shows superior effects to standard drug treatment.

View Source 2024
Meta-Analysis Men's Health / Urology

Effect of Combined Herbal Medicine and Electroacupuncture Treatment for Chronic Pelvic Pain Syndrome (CPPS): A Meta-Analysis

윤정호, 김상민, 이동현, et al. Prostate (2024)
12.3 points NIH-CPSI Reduction
789 subjects Total Subjects
11 RCTs Included RCTs

Summary

A meta-analysis analyzing the effect of combined herbal medicine and electroacupuncture treatment in male patients with CPPS (NIH Category IIIA/IIIB). Eleven randomized controlled trials (total 789 subjects) were included, and the combined herbal medicine-electroacupuncture group showed an average NIH-CPSI total score reduction of 12.3 points, significantly superior to the drug alone group.

Key Conclusion

Combined herbal medicine and electroacupuncture treatment is effective across all pain, urinary, and quality of life domains of chronic pelvic pain syndrome and shows superior effects to standard drug treatment.

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Systematic Review Men's Health / Urology

Protective Effect of Antioxidant Combined Herbal Medicine on Sperm DNA Damage: A Systematic Review

송영석, 안태진, 김재홍, et al.

Antioxidants (2023)

18.7% DFI Reduction
14 studies Included Studies
p<0.001 Statistical Significance

Antioxidant combined herbal medicine significantly reduces sperm DNA damage and is effective for protecting male fertility through oxidative stress regulation.

View Source 2023
Systematic Review Men's Health / Urology

Protective Effect of Antioxidant Combined Herbal Medicine on Sperm DNA Damage: A Systematic Review

송영석, 안태진, 김재홍, et al. Antioxidants (2023)
18.7% DFI Reduction
14 studies Included Studies
p<0.001 Statistical Significance

Summary

A systematic review analyzing the protective effect of antioxidant combined herbal medicine on sperm DNA damage in male infertility patients with sperm DNA damage (DFI ≥30%). Fourteen studies were included, and in Cornus officinalis-Schisandra-Lycium chinense-based prescriptions, DFI decreased by an average of 18.7%, and sperm intracellular ROS levels and MDA concentration also decreased significantly.

Key Conclusion

Antioxidant combined herbal medicine significantly reduces sperm DNA damage and is effective for protecting male fertility through oxidative stress regulation.

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Meta-Analysis Men's Health / Urology

Comparative Effect of Combined Herbal Medicine and Tadalafil Treatment for Benign Prostatic Hyperplasia: A Meta-Analysis

최재원, 박영훈, 이동수, et al.

World Journal of Urology (2024)

3.8 points Additional IPSS Reduction
2.1 mL/s Additional Qmax Increase
612 subjects Total Subjects

Combined herbal medicine-tadalafil treatment significantly additionally improves lower urinary tract symptoms and urodynamic indicators in BPH patients compared with single treatment.

View Source 2024
Meta-Analysis Men's Health / Urology

Comparative Effect of Combined Herbal Medicine and Tadalafil Treatment for Benign Prostatic Hyperplasia: A Meta-Analysis

최재원, 박영훈, 이동수, et al. World Journal of Urology (2024)
3.8 points Additional IPSS Reduction
2.1 mL/s Additional Qmax Increase
612 subjects Total Subjects

Summary

A meta-analysis comparing the effects of herbal medicine + tadalafil combination and tadalafil alone in benign prostatic hyperplasia (BPH) patients. Nine randomized controlled trials (total 612 subjects) were included, and the combined group showed an average 3.8 additional points reduction in IPSS and an average 2.1 mL/s additional increase in Qmax, confirming the additive effect of combined treatment.

Key Conclusion

Combined herbal medicine-tadalafil treatment significantly additionally improves lower urinary tract symptoms and urodynamic indicators in BPH patients compared with single treatment.

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Cohort Study Men's Health / Urology

Concurrent Treatment Effect of Herbal Medicine for Sleep Disorders and Nocturia in Middle-Aged Men: A Cohort Study

정호진, 윤서현, 강병준, et al.

Sleep Medicine (2024)

45.1% PSQI Improvement Rate
54.8% Nocturia Reduction Rate
110 subjects Cohort Size

Sanjoin-tang combined with Chukcheon-hwan is effective for concurrent treatment of sleep disorders and nocturia and is an integrated approach blocking the vicious cycle between the two symptoms.

View Source 2024
Cohort Study Men's Health / Urology

Concurrent Treatment Effect of Herbal Medicine for Sleep Disorders and Nocturia in Middle-Aged Men: A Cohort Study

정호진, 윤서현, 강병준, et al. Sleep Medicine (2024)
45.1% PSQI Improvement Rate
54.8% Nocturia Reduction Rate
110 subjects Cohort Size

Summary

A cohort study analyzing the effect of Sanjoin-tang combined with Chukcheon-hwan in 110 men aged 45-65 simultaneously complaining of sleep disorders and nocturia. After 12 weeks of administration, PSQI improved from an average of 14.2 to 7.8, and nocturnal urination frequency decreased from an average of 3.1 to 1.4 times. Simultaneous improvement of both symptoms was confirmed.

Key Conclusion

Sanjoin-tang combined with Chukcheon-hwan is effective for concurrent treatment of sleep disorders and nocturia and is an integrated approach blocking the vicious cycle between the two symptoms.

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