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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 92 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Cohort Study Women's Health / Infertility

Hemoglobin Improvement Effect of Herbal Medicine (Sipjeondaebo-tang) Treatment for Pregnancy Anemia: A Cohort Study

탁서연, 피지현, 도하영, et al.

Journal of Perinatal Medicine (2024)

2.4 g/dL Hb increase (herbal)
88 patients Study population
0.8 g/dL Superiority over iron

Sipjeondaebo-tang is more effective than iron supplements for hemoglobin improvement of pregnancy anemia, with excellent gastrointestinal tolerability.

View Source 2024
Cohort Study Women's Health / Infertility

Hemoglobin Improvement Effect of Herbal Medicine (Sipjeondaebo-tang) Treatment for Pregnancy Anemia: A Cohort Study

탁서연, 피지현, 도하영, et al. Journal of Perinatal Medicine (2024)
2.4 g/dL Hb increase (herbal)
88 patients Study population
0.8 g/dL Superiority over iron

Summary

A cohort study comparing Sipjeondaebo-tang administration group (44 patients) and iron supplement alone group (44 patients) in 88 pregnant women with mid-pregnancy anemia (Hb less than 10 g/dL). After 8 weeks, hemoglobin increased by an average of 2.4 g/dL in the herbal medicine combination group, superior to the iron supplement alone group (1.6 g/dL). Gastrointestinal side effects including dyspepsia were also fewer in the herbal medicine group.

Key Conclusion

Sipjeondaebo-tang is more effective than iron supplements for hemoglobin improvement of pregnancy anemia, with excellent gastrointestinal tolerability.

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Cross-Sectional Women's Health / Infertility

Psychological Satisfaction and Stress Reduction Effect of Korean Medicine Treatment for Infertile Couples: A Cross-Sectional Study

길예진, 안다솜, 류서현, et al.

Human Reproduction (2023)

246 couples Study population
Significant Stress reduction
High Treatment satisfaction

Combined Korean medicine treatment reduces psychological stress of infertile couples and increases treatment satisfaction, improving overall experience of assisted reproductive technology process.

View Source 2023
Cross-Sectional Women's Health / Infertility

Psychological Satisfaction and Stress Reduction Effect of Korean Medicine Treatment for Infertile Couples: A Cross-Sectional Study

길예진, 안다솜, 류서현, et al. Human Reproduction (2023)
246 couples Study population
Significant Stress reduction
High Treatment satisfaction

Summary

A cross-sectional study evaluating psychological satisfaction, stress levels, and quality of life in 246 infertile couples undergoing combined Korean medicine treatment with assisted reproductive technology. The Korean medicine combination group showed significantly lower infertility-related stress (FPI) scores, higher treatment process satisfaction, and improved marital relationship satisfaction.

Key Conclusion

Combined Korean medicine treatment reduces psychological stress of infertile couples and increases treatment satisfaction, improving overall experience of assisted reproductive technology process.

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Cohort Study Women's Health / Infertility

Cohort Study of Moxibustion Treatment for Menopausal Insomnia

Noh HM, Park MJ, Yun YG, et al.

Climacteric (2023)

5.8 points PSQI Reduction
100 subjects Participants
12 weeks Follow-up Period

Moxibustion treatment safely improves menopausal insomnia and accompanying symptoms.

View Source 2023
Cohort Study Women's Health / Infertility

Cohort Study of Moxibustion Treatment for Menopausal Insomnia

Noh HM, Park MJ, Yun YG, et al. Climacteric (2023)
5.8 points PSQI Reduction
100 subjects Participants
12 weeks Follow-up Period

Summary

One hundred menopausal insomnia women were followed for 12 weeks, divided into moxibustion treatment and non-treatment groups. PSQI decreased by 5.8 points and menopausal symptoms also simultaneously improved in the moxibustion group.

Key Conclusion

Moxibustion treatment safely improves menopausal insomnia and accompanying symptoms.

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Systematic Review Women's Health / Infertility

Safety and Efficacy of Acupuncture Treatment for Postpartum Depression: A Systematic Review

Noh HM, Yoon JY, Park JE, et al.

Archives of Womens Mental Health (2024)

12 studies Analyzed Studies
EPDS reduction Main Effect
Breastfeeding safe Safety

Acupuncture treatment is a safe and effective non-pharmacological treatment option for postpartum depression.

View Source 2024
Systematic Review Women's Health / Infertility

Safety and Efficacy of Acupuncture Treatment for Postpartum Depression: A Systematic Review

Noh HM, Yoon JY, Park JE, et al. Archives of Womens Mental Health (2024)
12 studies Analyzed Studies
EPDS reduction Main Effect
Breastfeeding safe Safety

Summary

Twelve studies evaluating the effect of acupuncture treatment for postpartum depression were systematically reviewed. Acupuncture treatment showed significant effects on EPDS score reduction and was confirmed to be safely applicable during breastfeeding.

Key Conclusion

Acupuncture treatment is a safe and effective non-pharmacological treatment option for postpartum depression.

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RCT Women's Health / Infertility

Randomized Double-Blind Trial of Gamisoyo-san for Menopausal Depression and Anxiety

Yoo JH, Ahn YJ, Kim DI, et al.

Menopause (2024)

44% Anxiety Reduction
38% Depression Reduction
Double-blind Study Design

Gamisoyo-san is an effective herbal treatment for menopausal depression and anxiety.

View Source 2024
RCT Women's Health / Infertility

Randomized Double-Blind Trial of Gamisoyo-san for Menopausal Depression and Anxiety

Yoo JH, Ahn YJ, Kim DI, et al. Menopause (2024)
44% Anxiety Reduction
38% Depression Reduction
Double-blind Study Design

Summary

One hundred women with menopausal depressive and anxiety symptoms were double-blind compared between Gamisoyo-san and placebo groups for 12 weeks. HADS anxiety (-44%) and depression (-38%) scores decreased significantly in the Gamisoyo-san group.

Key Conclusion

Gamisoyo-san is an effective herbal treatment for menopausal depression and anxiety.

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Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al.

Osteoporosis International (2023)

14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

View Source 2023
Meta-Analysis Women's Health / Infertility

Impact of Combined Tonifying Prescription and Exercise on Bone Density in Women with Pre-Osteoporosis: A Meta-Analysis

Yoon HJ, Choi SY, Kim EH, et al. Osteoporosis International (2023)
14 RCTs Analyzed RCTs
Lumbar BMD +0.034 Bone density improvement
Osteopenic women Target

Summary

Fourteen RCTs evaluating the combined effect of tonifying herbal medicine and exercise in osteopenic women were meta-analyzed. The combination group showed significant additional improvements compared to exercise alone in lumbar bone density (MD: 0.034 g/cm²) and femoral bone density (MD: 0.021 g/cm²).

Key Conclusion

Combined tonifying herbal medicine and exercise effectively improves bone density in osteopenic women and contributes to osteoporosis prevention.

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Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al.

Journal of Affective Disorders (2023)

80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

View Source 2023
Cohort Study Women's Health / Infertility

Effect of Korean Medicine Treatment for Postpartum Depression: A Prospective Cohort Study

Yun SH, Kim EJ, Li Y, et al. Journal of Affective Disorders (2023)
80 subjects Participants
61% EPDS Improvement Rate
12 weeks Follow-up Period

Summary

A cohort study following 80 women with postpartum depression for 12 weeks, divided into combined herbal medicine-acupuncture and general management groups. EPDS scores decreased significantly in the Korean medicine treatment group, with higher breastfeeding continuation rates.

Key Conclusion

Korean medicine treatment is effective for postpartum depression management and is a safe treatment option compatible with breastfeeding.

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RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al.

Menopause (2025)

100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

View Source 2025
RCT Women's Health / Infertility

Effect of Gamisoyo-san on Menopausal Depression in Middle-Aged Women: An RCT

Woo JK, Ahn MH, et al. Menopause (2025)
100 subjects Participants
57% BDI Improvement Rate
12 weeks Treatment Period

Summary

One hundred middle-aged women complaining of menopausal depressive symptoms were randomly assigned to Gamisoyo-san and placebo groups and compared for 12 weeks. BDI and menopausal symptom scores improved significantly in the Gamisoyo-san group.

Key Conclusion

Gamisoyo-san effectively alleviates menopausal depressive symptoms and accompanying menopausal symptoms.

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RCT Women's Health / Infertility

Effect of Personalized Herbal Prescription Combined with Acupuncture on Dysmenorrhea Improvement

Jang JB, Kim DC, Park KM, et al.

Journal of Alternative and Complementary Medicine (2023)

80 subjects Participants
VAS 62% reduction Pain Improvement
3 cycles Observation Period

The combination of personalized herbal medicine and acupuncture demonstrates synergistic effects in managing dysmenorrhea.

View Source 2023
RCT Women's Health / Infertility

Effect of Personalized Herbal Prescription Combined with Acupuncture on Dysmenorrhea Improvement

Jang JB, Kim DC, Park KM, et al. Journal of Alternative and Complementary Medicine (2023)
80 subjects Participants
VAS 62% reduction Pain Improvement
3 cycles Observation Period

Summary

Eighty women with primary dysmenorrhea were divided into herbal medicine alone, acupuncture alone, herbal medicine+acupuncture combined, and analgesic control groups and observed for 3 menstrual cycles. The combined group showed the greatest reduction in VAS pain scores.

Key Conclusion

The combination of personalized herbal medicine and acupuncture demonstrates synergistic effects in managing dysmenorrhea.

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Meta-Analysis Women's Health / Infertility

Effect of Personalized Herbal Prescriptions on Menopausal Syndrome: A Systematic Review and Meta-Analysis

Choi JE, Lee HW, Kim YI, et al.

Maturitas (2023)

21 studies Included Studies
1,847 subjects Total Participants
KI score 38% reduction Symptom Improvement

Personalized herbal prescriptions effectively alleviate overall symptoms of menopausal syndrome and can serve as a complement to hormone replacement therapy.

View Source 2023
Meta-Analysis Women's Health / Infertility

Effect of Personalized Herbal Prescriptions on Menopausal Syndrome: A Systematic Review and Meta-Analysis

Choi JE, Lee HW, Kim YI, et al. Maturitas (2023)
21 studies Included Studies
1,847 subjects Total Participants
KI score 38% reduction Symptom Improvement

Summary

A meta-analysis of 21 clinical studies investigating the efficacy of personalized herbal medicine for menopausal syndrome. Kupperman Index and hot flash frequency significantly decreased.

Key Conclusion

Personalized herbal prescriptions effectively alleviate overall symptoms of menopausal syndrome and can serve as a complement to hormone replacement therapy.

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Systematic Review Women's Health / Infertility

Effect of Combined Herbal Medicine on Endometrial Receptivity in Infertile Women: A Systematic Review

Kim SH, Park JW, Lee MK, et al.

Evidence-Based Complementary and Alternative Medicine (2023)

78% Endometrial improvement rate
1,240 patients Participants

Combined herbal medicine can play a positive role in endometrial environment improvement in infertile women, with potential for combined treatment with assisted reproductive technology suggested.

View Source 2023
Systematic Review Women's Health / Infertility

Effect of Combined Herbal Medicine on Endometrial Receptivity in Infertile Women: A Systematic Review

Kim SH, Park JW, Lee MK, et al. Evidence-Based Complementary and Alternative Medicine (2023)
78% Endometrial improvement rate
1,240 patients Participants

Summary

Effects of combined herbal medicine on endometrial receptivity improvement in infertile women were systematically analyzed. A meta-analysis was performed including 18 RCTs. The combined herbal medicine group showed significant improvements in endometrial thickness and blood flow.

Key Conclusion

Combined herbal medicine can play a positive role in endometrial environment improvement in infertile women, with potential for combined treatment with assisted reproductive technology suggested.

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RCT Women's Health / Infertility

Effect of Acupuncture on IVF Success Rates: A Randomized Controlled Trial

Lee JH, Choi YS, Yoon HJ, et al.

Fertility and Sterility (2024)

42.3% Implantation rate improvement
180 patients Participants

Combined acupuncture before and after IVF was confirmed to have significant effects on improving implantation rates.

View Source 2024
RCT Women's Health / Infertility

Effect of Acupuncture on IVF Success Rates: A Randomized Controlled Trial

Lee JH, Choi YS, Yoon HJ, et al. Fertility and Sterility (2024)
42.3% Implantation rate improvement
180 patients Participants

Summary

Acupuncture combination and control groups were compared in 180 infertile women undergoing IVF. Implantation rates and pregnancy maintenance rates were statistically significantly higher in the acupuncture group.

Key Conclusion

Combined acupuncture before and after IVF was confirmed to have significant effects on improving implantation rates.

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