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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al.

Supportive Care in Cancer (2024)

55% Nausea↓
42% Appetite↑
60 subjects Participants

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

View Source 2024
RCT Digestive Disorders

Randomized Controlled Trial of Herbal Medicine for Post-Chemotherapy Digestive Side Effects

Han SJ, Kim DH, Lee JA, et al. Supportive Care in Cancer (2024)
55% Nausea↓
42% Appetite↑
60 subjects Participants

Summary

Sixty patients with chemotherapy-related digestive side effects (nausea, anorexia, diarrhea) were compared over 6 weeks between Yukgunja-tang and placebo groups. The herbal group showed significant improvement in nausea (-55%) and appetite (+42%).

Key Conclusion

Yukgunja-tang is useful for the effective management of chemotherapy-related digestive side effects.

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Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al.

Brain Imaging and Behavior (2024)

ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Herbal medicine modulates IBS at the central level of the brain-gut axis.

View Source 2024
Before-After Digestive Disorders

fMRI Study of Herbal Medicine for the Brain-Gut Axis in IBS Patients: A Pre-Post Comparison

Kwon CY, Song JH, Lee DH, et al. Brain Imaging and Behavior (2024)
ACC activity↓ Central Modulation
30 subjects Participants
fMRI Neuroimaging Confirmation

Summary

Thirty IBS patients received Tongxieyao-fang for 8 weeks, with fMRI comparison of brain activity. Hyperactivity in the anterior cingulate cortex (ACC) and insula decreased, and IBS-SSS showed concurrent improvement.

Key Conclusion

Herbal medicine modulates IBS at the central level of the brain-gut axis.

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Cohort Study Digestive Disorders

Cohort Study of Combined Herbal Medicine and Lifestyle Modification for GERD

Han CH, Seo JY, Moon KW, et al.

Journal of Gastroenterology and Hepatology (2024)

25% Relapse Rate
130 subjects Participants
After PPI discontinuation Long-term Effect

The combination of herbal medicine and lifestyle modification is more effective than PPI in long-term relapse prevention of GERD.

View Source 2024
Cohort Study Digestive Disorders

Cohort Study of Combined Herbal Medicine and Lifestyle Modification for GERD

Han CH, Seo JY, Moon KW, et al. Journal of Gastroenterology and Hepatology (2024)
25% Relapse Rate
130 subjects Participants
After PPI discontinuation Long-term Effect

Summary

One hundred thirty GERD patients were followed for 24 weeks, divided into herbal medicine plus lifestyle modification and PPI-alone groups. The Korean medicine approach group showed a relapse rate of 25% after PPI discontinuation, significantly lower than 55% in the PPI group.

Key Conclusion

The combination of herbal medicine and lifestyle modification is more effective than PPI in long-term relapse prevention of GERD.

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Systematic Review Women's Health / Infertility

Impact of Herbal Medicine Treatment on Ovarian Reserve and Pregnancy Success Rate in Infertile Women: A Systematic Review

김수진, 박은혜, 이정민, et al.

Journal of Korean Medicine (2024)

0.8 ng/mL AMH mean increase
18 studies Analyzed studies
1,420 patients Total participants

Herbal medicine treatment has significant effects on AMH and AFC improvement in infertile women with diminished ovarian reserve, and can be utilized as an ovarian function improvement strategy before assisted reproductive technology.

View Source 2024
Systematic Review Women's Health / Infertility

Impact of Herbal Medicine Treatment on Ovarian Reserve and Pregnancy Success Rate in Infertile Women: A Systematic Review

김수진, 박은혜, 이정민, et al. Journal of Korean Medicine (2024)
0.8 ng/mL AMH mean increase
18 studies Analyzed studies
1,420 patients Total participants

Summary

A systematic review analyzing ovarian reserve (AMH, AFC) improvement effects of herbal medicine treatment in infertile women. Analysis of 18 studies (1,420 patients) showed AMH levels increased by an average of 0.8 ng/mL in the herbal medicine administration group, with significantly increased antral follicle count (AFC). Effects were particularly pronounced in advanced infertility patients aged 35 or older.

Key Conclusion

Herbal medicine treatment has significant effects on AMH and AFC improvement in infertile women with diminished ovarian reserve, and can be utilized as an ovarian function improvement strategy before assisted reproductive technology.

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Meta-Analysis Women's Health / Infertility

Systematic Review and Meta-Analysis on Effect of Herbal Medicine Treatment for Women with Ovulation Disorder

김영은, 최지혜, 송유진, et al.

European Journal of Integrative Medicine (2023)

74.3% Herbal medicine group ovulation rate
22 studies Analyzed studies
12.2%p Ovulation rate improvement

Herbal medicine treatment is effective for ovulation rate improvement in women with ovulation disorder and is a safe alternative with fewer side effects compared to existing ovulation induction agents.

View Source 2023
Meta-Analysis Women's Health / Infertility

Systematic Review and Meta-Analysis on Effect of Herbal Medicine Treatment for Women with Ovulation Disorder

김영은, 최지혜, 송유진, et al. European Journal of Integrative Medicine (2023)
74.3% Herbal medicine group ovulation rate
22 studies Analyzed studies
12.2%p Ovulation rate improvement

Summary

A meta-analysis of 22 RCTs (1,856 patients) evaluating effects of herbal medicine treatment in women with ovulation disorder. Ovulation rate of the herbal medicine administration group was 74.3%, significantly higher than the clomiphene alone group (62.1%), with also improved follicle maturation and endometrial thickness. Adverse event incidence was markedly lower in the herbal medicine group.

Key Conclusion

Herbal medicine treatment is effective for ovulation rate improvement in women with ovulation disorder and is a safe alternative with fewer side effects compared to existing ovulation induction agents.

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Before-After Women's Health / Infertility

Effect of Combined Herbal Medicine and Moxibustion Treatment on Progesterone Levels in Women with Luteal Phase Defect (LPD)

정아름, 김서현, 이은비, et al.

대한한의학회지 (2024)

8.7 ng/mL Post-treatment progesterone
2.3 days Luteal phase extension
64 patients Study population

Combined herbal medicine and moxibustion treatment is effective for promoting progesterone secretion and normalizing luteal phase duration in women with luteal phase defect.

View Source 2024
Before-After Women's Health / Infertility

Effect of Combined Herbal Medicine and Moxibustion Treatment on Progesterone Levels in Women with Luteal Phase Defect (LPD)

정아름, 김서현, 이은비, et al. 대한한의학회지 (2024)
8.7 ng/mL Post-treatment progesterone
2.3 days Luteal phase extension
64 patients Study population

Summary

A pre-post comparison study combining herbal medicine (modified Gwibi-tang) and moxibustion treatment at CV4 in 64 women diagnosed with luteal phase defect. After 3 months of treatment, luteal phase progesterone levels significantly increased from an average of 4.2 ng/mL to 8.7 ng/mL, with luteal phase duration also extended by an average of 2.3 days.

Key Conclusion

Combined herbal medicine and moxibustion treatment is effective for promoting progesterone secretion and normalizing luteal phase duration in women with luteal phase defect.

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Cohort Study Women's Health / Infertility

Menstrual Cycle Normalization Effect of Herbal Medicine Treatment for Menstrual Irregularity: A Prospective Cohort Study

이하은, 김나래, 정윤서, et al.

Journal of Ethnopharmacology (2024)

78.5% Cycle normalization rate
186 patients Study population
15.3% 12-month recurrence rate

Herbal medicine pattern treatment shows high effects on cycle normalization in women with menstrual irregularity, with effects maintained long-term even after treatment completion.

View Source 2024
Cohort Study Women's Health / Infertility

Menstrual Cycle Normalization Effect of Herbal Medicine Treatment for Menstrual Irregularity: A Prospective Cohort Study

이하은, 김나래, 정윤서, et al. Journal of Ethnopharmacology (2024)
78.5% Cycle normalization rate
186 patients Study population
15.3% 12-month recurrence rate

Summary

A 12-month prospective cohort study evaluating effects of herbal medicine treatment (Samul-tang, Jogyeongjongok-tang, and other pattern prescriptions) in 186 women with menstrual irregularity. After 6 months of treatment, 78.5% recovered to normal menstrual cycle range, with recurrence rate at 12-month follow-up only 15.3%.

Key Conclusion

Herbal medicine pattern treatment shows high effects on cycle normalization in women with menstrual irregularity, with effects maintained long-term even after treatment completion.

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Case Study Women's Health / Infertility

Menstrual Recovery Effect of Combined Acupuncture and Herbal Medicine Therapy for Women with Amenorrhea: A Case Report

송민지, 강다현, 조은별, et al.

대한한방부인과학회지 (2023)

87.5% Menstrual recovery rate
2.4 months Mean treatment duration
8 patients Number of cases

Combined acupuncture and herbal medicine therapy is effective for menstrual recovery in women with hypothalamic amenorrhea and contributes to normalization of hormonal axis function.

View Source 2023
Case Study Women's Health / Infertility

Menstrual Recovery Effect of Combined Acupuncture and Herbal Medicine Therapy for Women with Amenorrhea: A Case Report

송민지, 강다현, 조은별, et al. 대한한방부인과학회지 (2023)
87.5% Menstrual recovery rate
2.4 months Mean treatment duration
8 patients Number of cases

Summary

A case report of combined acupuncture (CV4, ZIGONG, SP6) and herbal medicine (modified Onkyeong-tang) treatment in 8 women with hypothalamic amenorrhea with no menstruation for 6 months or more. After average 2.4 months of treatment, menstruation recovered in 7 of 8 women, with FSH/LH ratio and E2 levels recovered to normal range.

Key Conclusion

Combined acupuncture and herbal medicine therapy is effective for menstrual recovery in women with hypothalamic amenorrhea and contributes to normalization of hormonal axis function.

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Before-After Women's Health / Infertility

Bleeding Volume Reduction Effect of Herbal Medicine (Goonggwigyoae-tang) Treatment for Menorrhagia: A Pre-Post Comparison Study

윤혜정, 김소담, 이채원, et al.

대한한의학회지 (2023)

42.9% Bleeding volume reduction rate
1.8 g/dL Hemoglobin elevation
58 patients Study population

Modified Goonggwigyoae-tang significantly reduces bleeding volume in women with menorrhagia and is effective for anemia improvement.

View Source 2023
Before-After Women's Health / Infertility

Bleeding Volume Reduction Effect of Herbal Medicine (Goonggwigyoae-tang) Treatment for Menorrhagia: A Pre-Post Comparison Study

윤혜정, 김소담, 이채원, et al. 대한한의학회지 (2023)
42.9% Bleeding volume reduction rate
1.8 g/dL Hemoglobin elevation
58 patients Study population

Summary

A study comparing pre- and post-administration of modified Goonggwigyoae-tang in 58 women with menorrhagia (menstrual volume 80 mL or more). After 3 months of treatment, menstrual volume decreased by 42.9% from an average of 126 mL to 72 mL, with hemoglobin levels also increasing by an average of 1.8 g/dL. Menstrual duration was also shortened by an average of 2.1 days.

Key Conclusion

Modified Goonggwigyoae-tang significantly reduces bleeding volume in women with menorrhagia and is effective for anemia improvement.

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Meta-Analysis Women's Health / Infertility

Fibroid Size Changes from Herbal Medicine (Gyejibokryeong-hwan) Treatment in Uterine Fibroid Patients: A Meta-Analysis

강은서, 허지민, 나윤정, et al.

Phytomedicine (2023)

31.5% Fibroid volume reduction rate
28 studies Analyzed studies
2,340 patients Total participants

Gyejibokryeong-hwan-based herbal medicine treatment is effective for uterine fibroid size reduction and shows synergistic effects when combined with Western medicine.

View Source 2023
Meta-Analysis Women's Health / Infertility

Fibroid Size Changes from Herbal Medicine (Gyejibokryeong-hwan) Treatment in Uterine Fibroid Patients: A Meta-Analysis

강은서, 허지민, 나윤정, et al. Phytomedicine (2023)
31.5% Fibroid volume reduction rate
28 studies Analyzed studies
2,340 patients Total participants

Summary

A meta-analysis of 28 studies (2,340 patients) evaluating effects of Gyejibokryeong-hwan-based herbal medicine treatment in uterine fibroid patients. Fibroid volume in the herbal medicine treatment group decreased by an average of 31.5%, with the herbal medicine plus mifepristone combination group showing the highest effect at 42.8% reduction. Need for surgery also significantly decreased.

Key Conclusion

Gyejibokryeong-hwan-based herbal medicine treatment is effective for uterine fibroid size reduction and shows synergistic effects when combined with Western medicine.

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Case Study Women's Health / Infertility

Effect of Combined Herbal Medicine and Pharmacopuncture Therapy for Pelvic Inflammatory Disease Sequelae: A Case Series

조예린, 백수현, 황지수, et al.

한방내과학회지 (2023)

69% Pain reduction rate
12 patients Number of cases
8 weeks Mean treatment duration

Combined herbal medicine and pharmacopuncture therapy is effective for pain relief and inflammation suppression of chronic pelvic inflammatory disease sequelae.

View Source 2023
Case Study Women's Health / Infertility

Effect of Combined Herbal Medicine and Pharmacopuncture Therapy for Pelvic Inflammatory Disease Sequelae: A Case Series

조예린, 백수현, 황지수, et al. 한방내과학회지 (2023)
69% Pain reduction rate
12 patients Number of cases
8 weeks Mean treatment duration

Summary

A case series of combined herbal medicine (modified Yongdamsagan-tang) and pharmacopuncture (bee venom pharmacopuncture) treatment in 12 women complaining of chronic pelvic inflammatory disease sequelae (chronic lower abdominal pain, increased discharge). After average 8 weeks of treatment, lower abdominal pain VAS decreased from 6.8 to 2.1, with also normalized inflammatory markers including CRP.

Key Conclusion

Combined herbal medicine and pharmacopuncture therapy is effective for pain relief and inflammation suppression of chronic pelvic inflammatory disease sequelae.

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RCT Women's Health / Infertility

Effect of Herbal Medicine (Gamisoyo-san) Treatment for Menopausal Night Sweats: A Randomized Controlled Trial

박소영, 김예진, 최다은, et al.

Climacteric (2023)

73% Night sweat reduction rate
84 patients Study population
45%p Difference vs placebo

Gamisoyo-san significantly reduces frequency of menopausal night sweats and is a safe treatment improving symptoms without hormonal level changes.

View Source 2023
RCT Women's Health / Infertility

Effect of Herbal Medicine (Gamisoyo-san) Treatment for Menopausal Night Sweats: A Randomized Controlled Trial

박소영, 김예진, 최다은, et al. Climacteric (2023)
73% Night sweat reduction rate
84 patients Study population
45%p Difference vs placebo

Summary

A double-blind RCT comparing Gamisoyo-san and placebo in 84 women with chief complaint of menopausal night sweats. After 12 weeks of administration, night sweat frequency decreased by 73% in the Gamisoyo-san group (placebo group 28%), with significantly improved sleep quality (PSQI) scores. Symptoms improved without changes in estrogen levels.

Key Conclusion

Gamisoyo-san significantly reduces frequency of menopausal night sweats and is a safe treatment improving symptoms without hormonal level changes.

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