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Geummaek Research

Research Papers

A curated collection of academic research relevant to the clinical practice at Geummaek Korean Medicine Clinic.

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Research Papers
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Total 1642 papers

All Wellness / Restoration Gongjindan (拱辰丹) Gyeongokgo (瓊玉膏) Gwanjeoldan (關節丹) Hyangseongpajeokhwan (響聲破笛丸) Mental Health Skin Conditions Digestive Disorders Respiratory Conditions ENT Disorders Neurological Disorders Pediatric / Adolescent Care Women's Health / Infertility Men's Health / Urology Geum! Maek! Capsule Diet Geum! Maek! Beauty Clinic Private Inpatient Room Traffic Accident Aftercare Pediatric Traffic Accident Workers' Compensation Lower Back Pain Neck Pain Shoulder Pain Elbow Pain Wrist / Hand Pain Hip Pain Knee Pain Ankle / Foot Pain TMJ Disorder
Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al.

Alzheimers Research & Therapy (2023)

25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

View Source 2023
Systematic Review Neurological Disorders

Neuroprotective Effect of Herbal Medicine for Dementia Prevention: A Systematic Review

Han SJ, Cho KH, Yoon JH, et al. Alzheimers Research & Therapy (2023)
25 studies Analyzed Studies
Aβ suppression Neuroprotective Mechanism
Hippocampal protection Structural Effect

Summary

Twenty-five studies evaluating the neuroprotective effect of dementia prevention herbal medicines (Jogudeung-san, Danggwijakyak-san, etc.) were systematically reviewed. Herbal medicine showed significant effects on amyloid beta accumulation inhibition and hippocampal neuron protection.

Key Conclusion

The neuroprotective effects of herbal medicine can contribute to dementia prevention strategies.

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Narrative Review Mental Health

Polysomnography-Based Effect of Herbal Medicine Prescriptions for Sleep Disorders: A Narrative Review

Choi AR, Lim JH, Han JM, et al.

Sleep Medicine Reviews (2024)

20 sources Reviewed Literature
Latency shortened Sleep Onset Improvement
Slow-wave sleep↑ Sleep Quality Improvement

Herbal medicine prescriptions improve PSG objective sleep indicators and show potential as alternatives to sleep medications.

View Source 2024
Narrative Review Mental Health

Polysomnography-Based Effect of Herbal Medicine Prescriptions for Sleep Disorders: A Narrative Review

Choi AR, Lim JH, Han JM, et al. Sleep Medicine Reviews (2024)
20 sources Reviewed Literature
Latency shortened Sleep Onset Improvement
Slow-wave sleep↑ Sleep Quality Improvement

Summary

Twenty articles on PSG-based effects of herbal medicine prescriptions for sleep disorders were reviewed. Sanjoin-tang and Ondam-tang showed effects on sleep latency shortening and slow-wave sleep increase.

Key Conclusion

Herbal medicine prescriptions improve PSG objective sleep indicators and show potential as alternatives to sleep medications.

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Case Study Respiratory Conditions

Effects of Herbal Medicine Adjuvant Treatment in Bronchiectasis Patients: A Case Series of 12 Cases

정가은, 김민수, 박윤아, et al.

한방재활의학과학회지 (2024)

54% Sputum volume reduction
12 patients Number of cases
12 weeks Treatment duration

Cheonggumganghwa-tang shows potential as adjunctive treatment for sputum reduction and acute exacerbation prevention in bronchiectasis patients.

View Source 2024
Case Study Respiratory Conditions

Effects of Herbal Medicine Adjuvant Treatment in Bronchiectasis Patients: A Case Series of 12 Cases

정가은, 김민수, 박윤아, et al. 한방재활의학과학회지 (2024)
54% Sputum volume reduction
12 patients Number of cases
12 weeks Treatment duration

Summary

A case series administering Cheonggumganghwa-tang for 12 weeks to 12 patients diagnosed with bronchiectasis. After treatment, daily sputum volume decreased by an average of 54%, with reduced acute exacerbation frequency and decreased hospitalizations. Bronchial wall thickening on chest CT also partially improved.

Key Conclusion

Cheonggumganghwa-tang shows potential as adjunctive treatment for sputum reduction and acute exacerbation prevention in bronchiectasis patients.

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RCT Respiratory Conditions

Immune-Enhancing Effect of Herbal Medicine for Influenza Prevention: A Randomized Controlled Trial

이윤호, 김소라, 박종민, et al.

Influenza and Other Respiratory Viruses (2023)

38% ILI occurrence reduction
180 patients Study population
1.6 days Symptom duration reduction

Modified Ssanghwa-tang shows potential as a preventive immune-enhancing agent during influenza epidemic season, and additional research targeting high-risk groups is needed.

View Source 2023
RCT Respiratory Conditions

Immune-Enhancing Effect of Herbal Medicine for Influenza Prevention: A Randomized Controlled Trial

이윤호, 김소라, 박종민, et al. Influenza and Other Respiratory Viruses (2023)
38% ILI occurrence reduction
180 patients Study population
1.6 days Symptom duration reduction

Summary

A randomized controlled trial comparing 8-week administration of modified Ssanghwa-tang versus placebo in 180 healthy adults during influenza epidemic season. The herbal medicine group showed 38% lower influenza-like illness (ILI) occurrence rate, with average 1.6-day shorter symptom duration when illness occurred.

Key Conclusion

Modified Ssanghwa-tang shows potential as a preventive immune-enhancing agent during influenza epidemic season, and additional research targeting high-risk groups is needed.

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Meta-Analysis Respiratory Conditions

Systematic Review and Meta-Analysis of Herbal Medicine Maintenance Treatment for Stable-Phase COPD Patients

정민재, 김도현, 박소연, et al.

Chronic Respiratory Disease (2023)

0.8 episodes Annual exacerbation reduction
15 studies Analyzed studies
33% Hospitalization rate reduction

Herbal medicine maintenance treatment shows significant effects on acute exacerbation prevention and hospitalization rate reduction in stable-phase COPD patients and may be included in long-term management strategies.

View Source 2023
Meta-Analysis Respiratory Conditions

Systematic Review and Meta-Analysis of Herbal Medicine Maintenance Treatment for Stable-Phase COPD Patients

정민재, 김도현, 박소연, et al. Chronic Respiratory Disease (2023)
0.8 episodes Annual exacerbation reduction
15 studies Analyzed studies
33% Hospitalization rate reduction

Summary

A meta-analysis of 15 RCTs (total 1,378 patients) evaluating acute exacerbation prevention effects of herbal medicine maintenance treatment for stable-phase COPD patients. The herbal medicine maintenance treatment group showed 0.8-fewer annual acute exacerbations, with 33% lower hospitalization rate.

Key Conclusion

Herbal medicine maintenance treatment shows significant effects on acute exacerbation prevention and hospitalization rate reduction in stable-phase COPD patients and may be included in long-term management strategies.

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RCT Respiratory Conditions

Herbal Medicine Treatment for Immunity Enhancement After Pediatric Respiratory Infections: A Randomized Controlled Trial

김보경, 이상현, 조해인, et al.

Pediatric Allergy and Immunology (2024)

45% Reinfection rate reduction
84 patients Study population
IgA increase Immune indicator improvement

Samchulgeonbi-tang is an effective herbal medicine prescription that promotes immunity recovery after pediatric respiratory infections and prevents reinfection.

View Source 2024
RCT Respiratory Conditions

Herbal Medicine Treatment for Immunity Enhancement After Pediatric Respiratory Infections: A Randomized Controlled Trial

김보경, 이상현, 조해인, et al. Pediatric Allergy and Immunology (2024)
45% Reinfection rate reduction
84 patients Study population
IgA increase Immune indicator improvement

Summary

A comparison of 8-week administration of Samchulgeonbi-tang versus vitamin control in 84 children aged 4-10 years suspected of immune decline after respiratory infection. The herbal medicine group showed 45% reduction in subsequent infection occurrence, with significant increases in salivary IgA and blood lymphocyte counts.

Key Conclusion

Samchulgeonbi-tang is an effective herbal medicine prescription that promotes immunity recovery after pediatric respiratory infections and prevents reinfection.

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Cohort Study ENT Disorders

Effect of Integrated Nasal Irrigation and Herbal Medicine Management Program for Allergic Rhinitis Patients: A Cohort Study

이지안, 김상혁, 박현진, et al.

Allergy, Asthma & Clinical Immunology (2023)

56% RQLQ improvement rate
106 patients Study population
16 weeks Program duration

Korean medicine integrated management program comprehensively improves quality of life in chronic allergic rhinitis patients and has the effect of reducing drug dependence.

View Source 2023
Cohort Study ENT Disorders

Effect of Integrated Nasal Irrigation and Herbal Medicine Management Program for Allergic Rhinitis Patients: A Cohort Study

이지안, 김상혁, 박현진, et al. Allergy, Asthma & Clinical Immunology (2023)
56% RQLQ improvement rate
106 patients Study population
16 weeks Program duration

Summary

A prospective cohort study performing 16-week integrated management program including nasal irrigation, Socheongryong-tang, and acupuncture in 106 patients with allergic rhinitis of 3 years or more duration. RQLQ (rhinitis quality of life) scores improved by an average of 56%, with reduced antihistamine use frequency.

Key Conclusion

Korean medicine integrated management program comprehensively improves quality of life in chronic allergic rhinitis patients and has the effect of reducing drug dependence.

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RCT ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Postnasal Drip Syndrome: A Randomized Controlled Trial

Yim YK, Kim JS, Won JH, et al.

Clinical Otolaryngology (2023)

62% Postnasal Drip VAS Reduction
88 subjects Participants
6 weeks Treatment Period

Combined acupuncture and herbal medicine demonstrates superior efficacy over antihistamines for symptom alleviation in postnasal drip syndrome.

View Source 2023
RCT ENT Disorders

Effect of Combined Acupuncture and Herbal Medicine for Postnasal Drip Syndrome: A Randomized Controlled Trial

Yim YK, Kim JS, Won JH, et al. Clinical Otolaryngology (2023)
62% Postnasal Drip VAS Reduction
88 subjects Participants
6 weeks Treatment Period

Summary

Eighty-eight patients with postnasal drip syndrome were assigned to acupuncture plus modified Changija-san or antihistamine groups for 6 weeks of treatment. The Korean medicine treatment group demonstrated a 62% reduction in postnasal drip VAS, significantly superior to the medication group (44%), with greater reduction in cough frequency.

Key Conclusion

Combined acupuncture and herbal medicine demonstrates superior efficacy over antihistamines for symptom alleviation in postnasal drip syndrome.

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Cohort Study ENT Disorders

Effect of Modified Bojungikgi-tang Administration on Daytime Sleepiness in Sleep Apnea Patients: A Cohort Study

Sohn DW, Park YC, Kim CH, et al.

Sleep and Breathing (2024)

5.6 points ESS Reduction
72 subjects Participants
8 weeks Treatment Period

Adjunctive modified Bojungikgi-tang enhances CPAP treatment effects in sleep apnea patients and improves daytime fatigue.

View Source 2024
Cohort Study ENT Disorders

Effect of Modified Bojungikgi-tang Administration on Daytime Sleepiness in Sleep Apnea Patients: A Cohort Study

Sohn DW, Park YC, Kim CH, et al. Sleep and Breathing (2024)
5.6 points ESS Reduction
72 subjects Participants
8 weeks Treatment Period

Summary

Seventy-two patients with moderate sleep apnea received combined CPAP therapy and modified Bojungikgi-tang for 8 weeks, with ESS and FOSQ measured. The combination group demonstrated an average 5.6-point reduction in ESS, significantly improved compared with CPAP monotherapy (3.2 points), with also enhanced daytime functional status (FOSQ).

Key Conclusion

Adjunctive modified Bojungikgi-tang enhances CPAP treatment effects in sleep apnea patients and improves daytime fatigue.

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Meta-Analysis Pediatric / Adolescent Care

Meta-Analysis of Herbal Medicine and Acupuncture Treatment for Children with Tic Disorder

Kim TH, Shin HK, Seo DW, et al.

European Child & Adolescent Psychiatry (2024)

15 studies Analyzed RCTs
-1.15 YGTSS SMD
Herbal medicine + acupuncture Optimal Combination

Korean medicine treatment is an effective adjunctive treatment for pediatric tic disorder.

View Source 2024
Meta-Analysis Pediatric / Adolescent Care

Meta-Analysis of Herbal Medicine and Acupuncture Treatment for Children with Tic Disorder

Kim TH, Shin HK, Seo DW, et al. European Child & Adolescent Psychiatry (2024)
15 studies Analyzed RCTs
-1.15 YGTSS SMD
Herbal medicine + acupuncture Optimal Combination

Summary

A meta-analysis of 15 RCTs evaluating the effect of Korean medicine treatment for pediatric tic disorder. The combined herbal medicine + acupuncture group showed significant reduction in YGTSS scores (SMD: -1.15).

Key Conclusion

Korean medicine treatment is an effective adjunctive treatment for pediatric tic disorder.

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Cross-Sectional Mental Health

Effect of Herbal Medicine (Chongmyung-tang) on Examinee Stress and Concentration: A Cross-Sectional Analysis

Han CH, Go GY, Min BW, et al.

Journal of Korean Medicine (2024)

200 patients Participants
27% Stress reduction
Concentration improved CPT improvement

Chongmyung-tang intake is significantly associated with stress management and improved concentration in examinees.

View Source 2024
Cross-Sectional Mental Health

Effect of Herbal Medicine (Chongmyung-tang) on Examinee Stress and Concentration: A Cross-Sectional Analysis

Han CH, Go GY, Min BW, et al. Journal of Korean Medicine (2024)
200 patients Participants
27% Stress reduction
Concentration improved CPT improvement

Summary

Stress (PSS), concentration (CPT), and academic performance were analyzed in 200 examinees according to their experience taking Chongmyung-tang. The user group showed 27% lower PSS scores and significantly higher CPT attention scores.

Key Conclusion

Chongmyung-tang intake is significantly associated with stress management and improved concentration in examinees.

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RCT Mental Health

Randomized Controlled Trial of Herbal Medicine (Sihosogan-san) for Post-Traumatic Stress Disorder

Shin WC, Kim MJ, Choi HS, et al.

Psychopharmacology (2024)

45% PCL-5 reduction
70 patients Participants
Hyperarousal reduced Key improvement

Sihosogan-san is effective as adjunctive therapy for PTSD in improving hyperarousal and avoidance symptoms.

View Source 2024
RCT Mental Health

Randomized Controlled Trial of Herbal Medicine (Sihosogan-san) for Post-Traumatic Stress Disorder

Shin WC, Kim MJ, Choi HS, et al. Psychopharmacology (2024)
45% PCL-5 reduction
70 patients Participants
Hyperarousal reduced Key improvement

Summary

Seventy PTSD patients were compared between a Sihosogan-san plus standard care group and a standard care alone group over 12 weeks. PCL-5 scores decreased by 45% and hyperarousal symptoms significantly improved in the combination group.

Key Conclusion

Sihosogan-san is effective as adjunctive therapy for PTSD in improving hyperarousal and avoidance symptoms.

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